State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, China.
J Mater Chem B. 2023 Feb 15;11(7):1416-1433. doi: 10.1039/d2tb02248f.
Although chemotherapy and photodynamic therapy (PDT) have been developed for fighting cancer, the complex and heterogeneous nature of tumors makes it difficult for a single therapy to completely inhibit tumor growth. In order to reduce multidrug resistance of cancer cells to chemotherapeutic drugs and overcome low PDT efficiency in the hypoxic tumor microenvironment (TME), chemo/PDT synergistic treatment has received much attention in recent years. Depending on the characteristic signals of TME, various drug delivery systems can be constructed to target tumors and improve the therapeutic efficacy and the pharmacokinetic profile of anticancer drugs. This review highlights the synergistic strategies, treatment protocols, and design of chemo/PDT co-therapy in recent years to explore its scope and limitations. Taking advantage of stimuli-responsive materials and active cancer-targeting agents, cancer-targeting synergistic therapy is presented and discussed, providing ideas and suggestions for the construction of chemo/PDT co-therapy "smart" nanocarriers.
尽管化疗和光动力疗法 (PDT) 已被开发用于治疗癌症，但肿瘤的复杂和异质性使得单一疗法难以完全抑制肿瘤生长。为了降低癌细胞对化疗药物的多药耐药性并克服低氧肿瘤微环境 (TME) 中的 PDT 效率低的问题，近年来，化疗/PDT 协同治疗受到了广泛关注。根据 TME 的特征信号，可以构建各种药物传递系统来靶向肿瘤，并提高抗癌药物的治疗效果和药代动力学特性。本综述重点介绍了近年来化疗/PDT 协同治疗的协同策略、治疗方案和设计，以探讨其范围和局限性。利用响应性材料和主动的癌症靶向试剂，提出并讨论了癌症靶向协同治疗，为构建化疗/PDT 协同治疗“智能”纳米载体提供了思路和建议。
