Goellner J R, Gharib H, Grant C S, Johnson D A
Section of Surgical Pathology, Mayo Clinic, Rochester, MN 55905.
Acta Cytol. 1987 Sep-Oct;31(5):587-90.
An experience with approximately 6,300 fine needle aspirations of the thyroid was reviewed. The cytologic results were negative in 65% of the aspirates, suspicious for malignancy in 11%, positive for malignancy in 4% and nondiagnostic in 20%. Sensitivity in 382 cases of known malignancy was 98%, and the specificity of a positive cytologic report for malignancy was 99%. Repeat aspiration on initially nondiagnostic cases produced diagnostic results in more than half of the cases. The major limitation of the technique seems to be the lack of specificity in the group whose results are suspicious for malignancy, in large part due to an inability to separate cellular follicular or Hürthle-cell adenomas from follicular or Hürthle-cell carcinomas. The protocols for obtaining and processing the aspirates are briefly summarized.
回顾了约6300例甲状腺细针穿刺的经验。细胞学检查结果显示，65%的穿刺样本为阴性，11%可疑为恶性，4%确诊为恶性，20%无法诊断。在382例已知恶性肿瘤的病例中，敏感性为98%，细胞学报告阳性诊断恶性肿瘤的特异性为99%。对最初无法诊断的病例进行重复穿刺，半数以上病例得到了诊断结果。该技术的主要局限性似乎在于结果可疑为恶性的组中缺乏特异性，这在很大程度上是由于无法将细胞性滤泡性腺瘤或许特莱细胞腺瘤与滤泡癌或许特莱细胞癌区分开来。简要总结了获取和处理穿刺样本的方案。
