Tuteja Minkal, Nagpal Kalpana
Gurugram Global College of Pharmacy, Farrukhnagar, Gurugram, Haryana, 122506, India.
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, UP-201303, India.
Crit Rev Ther Drug Carrier Syst. 2023;40(2):83-124. doi: 10.1615/CritRevTherDrugCarrierSyst.2022042252.
This work is an effort to first introduce plant-based gums and discussing their drug delivery applications. The composition of these plant gums and their major characteristics, which make them suitable as pharmaceutical excipients are also described in detail. The various modifications methods such as physical and chemical modifications of gums and polysaccharides have been discussed along with their applications in different fields. Consequently, plant-based gums modification such as etherification and grafting is attracting much scientific attention to satisfy industrial demand. The evaluation tests to characterize gum-based drug delivery systems have been summarized. The release behavior of drug from plant-gum-based drug delivery is being discussed. Thus, this review is an attempt to critically summarize different aspect of plant-gum-based polysaccharides to be utilized in drug delivery systems having potential industrial applications.
这项工作首先致力于介绍植物性胶并讨论其药物递送应用。还详细描述了这些植物胶的组成及其使其适合作为药物赋形剂的主要特性。已经讨论了各种改性方法，例如胶和多糖的物理和化学改性及其在不同领域的应用。因此，基于植物的胶的改性，如醚化和接枝，正吸引着众多科学关注以满足工业需求。总结了表征基于胶的药物递送系统的评估测试。正在讨论药物从基于植物胶的药物递送中的释放行为。因此，本综述旨在批判性地总结基于植物胶的多糖在具有潜在工业应用的药物递送系统中不同方面的情况。
