Shri Shankaracharya Institute of Pharmaceutical Science and Research, Junwani, Bhilai 490020, Chhattisgarh, India.
School of Pharmacy, Techno India University, Kolkata 700091, West Bengal, India.
Int J Biol Macromol. 2022 Jun 1;209(Pt B):2197-2212. doi: 10.1016/j.ijbiomac.2022.04.201. Epub 2022 May 1.
Diverse properties of natural gums have made them quite useful for various pharmaceutical applications. However, they suffer from various problems, including unregulated hydration rates, microbial degradation, and decline in viscosity during warehousing. Among various chemical procedures for modification of gums, carboxymethylation has been widely studied due to its simplicity and efficiency. Despite the availability of numerous research articles on natural gums and their uses, a comprehensive review on carboxymethylation of natural gums and their applications in the pharmaceutical and other biomedical fields is not published until now. This review outlines the classification of gums and their derivatization methods. Further, we have discussed various techniques of carboxymethylation, process of determination of degree of substitution, and functionalization pattern of substituted gums. Detailed information about the application of carboxymethyl gums as drug delivery carriers has been described. The article also gives a brief account on tissue engineering and cell delivery potential of carboxymethylated gums.
天然胶的多种特性使其在各种药物应用中非常有用。然而，它们存在各种问题，包括水合速率不受控制、微生物降解以及在储存过程中粘度下降。在对胶进行化学改性的各种方法中，由于其简单性和高效性，羧甲基化得到了广泛的研究。尽管有大量关于天然胶及其用途的研究文章，但直到现在才发表了关于天然胶羧甲基化及其在药物和其他生物医学领域应用的综合评论。本文概述了胶的分类和它们的衍生化方法。此外，我们还讨论了各种羧甲基化技术、取代度的测定过程以及取代胶的功能化模式。详细介绍了羧甲基胶作为药物传递载体的应用。本文还简要介绍了羧甲基化胶在组织工程和细胞传递方面的潜力。
