From the Sorbonne Paris Nord University, INSERM U1153, INRAE U1125, CNAM, Nutritional Epidemiology Research Team (EREN), Centre of Research in Epidemiology and Statistics - University of Paris Cité (CRESS), Bobigny, France.
Univ. Lille, INSERM, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, 59000 Lille, France.
J Pediatr Gastroenterol Nutr. 2023 Apr 1;76(4):e71-e76. doi: 10.1097/MPG.0000000000003716. Epub 2023 Feb 2.
This study assessed the reliability and validity of the IMPACT-III questionnaire, a health-related quality of life (HRQoL) instrument, in French children with inflammatory bowel disease (IBD).
Eighty-four children and adolescents (45 boys, aged 14.3 ± 2.7 years) were included in a validation study of the IMPACT-III questionnaire. Patients completed 2 questionnaires for measuring HRQoL: the IMPACT-III and the Pediatric Quality of Life Inventory 4.0 Generic Core Scale (PedsQL). Internal consistency was assessed using Cronbach α. Factor analysis was performed on data from the IMPACT-III to help construct domains. Concurrent validity was assessed by calculating Spearman correlation coefficients.
Cronbach α for the PedsQL total score was good (0.89). The most robust factor solution was a 3-domain structure: (a) Concerns, (b) Body Image and Physical Condition, and (c) Symptoms and Socializing. All domains had good reliability (0.674-0.863). Only 2 items had to be removed. Discriminant validity was demonstrated by significant differences ( P < 0.001) in median IMPACT-III scores between inactive and active disease for the total score (83.3 vs 72.0), and for Concerns ( P < 0.002) and Symptoms and Socializing ( P < 0.001).
These results suggest that IMPACT-III appears to be a useful instrument for measuring HRQoL in French children with IBD.
本研究评估了 IMPACT-III 问卷作为一种健康相关生活质量（HRQoL）工具在法国炎症性肠病（IBD）儿童中的可靠性和有效性。
84 名儿童和青少年（45 名男性，年龄 14.3±2.7 岁）参与了 IMPACT-III 问卷的验证研究。患者完成了 2 份用于测量 HRQoL 的问卷：IMPACT-III 和儿科生活质量问卷 4.0 通用核心量表（PedsQL）。采用 Cronbach α 评估内部一致性。对 IMPACT-III 数据进行因子分析以帮助构建域。通过计算 Spearman 相关系数评估同时效度。
PedsQL 总分的 Cronbach α 较好（0.89）。最稳健的因素解决方案是 3 个域结构：（a）关注，（b）身体形象和身体状况，以及（c）症状和社交。所有领域的可靠性均良好（0.674-0.863）。仅需删除 2 个项目。通过总得分（83.3 对 72.0）和关注（P＜0.002）以及症状和社交（P＜0.001）之间疾病不活跃和活跃时 IMPACT-III 评分中位数的显著差异证明了判别有效性。
这些结果表明，IMPACT-III 似乎是一种用于衡量法国 IBD 儿童 HRQoL 的有用工具。
