Department of Pediatrics, Polytechnic University of Marche, G. Salesi Children's Hospital, Via Corridoni 11, 60123, Ancona, Italy.
Department of Maternal and Child Health, Pediatric Gastroenterology and Liver Unit, Umberto I Hospital, Sapienza University of Rome, Viale del Policlinico 105, 00161, Rome, Italy.
Sci Rep. 2021 Sep 10;11(1):18076. doi: 10.1038/s41598-021-97661-1.
Improving the quality of life (QoL) is crucial in the management of pediatric inflammatory bowel disease (IBD). We aimed to (1) Validate the IMPACT-III questionnaire in Italian IBD children; (2) explore factors associated to QoL in pediatric IBD. Internal consistency, concurrent validity, discriminant validity and reproducibility of the Italian version of the IMPACT-III questionnaire was measured in IBD children/adolescents in 8 centers. Associations between patient and disease characteristics and the IMPACT-III domains were analyzed through quantile regression analysis. The IMPACT-III questionnaire, collected in 282 children with IBD (median age: 14.8 years; IQR 12.4-16.4) showed a median total score of 76 (IQR 67-83). Female gender, active disease and age were negatively associated with the total IMPACT-III score. Specifically, female gender was negatively associated with the Bowel/Systemic Symptoms, Emotional and Treatment domain scores, while disease activity was significantly associated with Bowel Symptoms and Treatment/Interventions reported QoL. The IMPACT- III showed good internal consistency (Cronbach's alpha coefficient = 0.87, 95% CI 0.85-0.89) and reproducibility (Concordance Correlation Coefficient = 0.66, 95% CI 0.57-0.74). In Italian children with IBD active disease, female gender and adolescence are associated to a worse QoL, indicating the need of more attention in this subgroup of young patients. IMPACT-III questionnaire is a reliable instrument to measure QoL in Italian children.
提高生活质量（QoL）是小儿炎症性肠病（IBD）管理的关键。我们旨在：（1）验证意大利语 IBD 儿童的 IMPACT-III 问卷；（2）探讨与小儿 IBD 相关的 QoL 因素。在 8 个中心，对 IBD 儿童/青少年进行了 IMPACT-III 问卷的内部一致性、并行效度、判别效度和可重复性测量。通过分位数回归分析，分析了患者和疾病特征与 IMPACT-III 各领域之间的关联。收集了 282 名 IBD 儿童（中位数年龄：14.8 岁；IQR 12.4-16.4）的 IMPACT-III 问卷，总分为 76 分（IQR 67-83）。女性、活动期疾病和年龄与总 IMPACT-III 评分呈负相关。具体来说，女性与肠/全身症状、情绪和治疗领域评分呈负相关，而疾病活动与肠道症状和治疗/干预报告的 QoL 显著相关。IMPACT-III 具有良好的内部一致性（Cronbach's alpha 系数=0.87，95%CI 0.85-0.89）和可重复性（一致性相关系数=0.66，95%CI 0.57-0.74）。在意大利有活动期疾病的 IBD 儿童中，女性、性别和青春期与较差的 QoL 相关，表明需要对这组年轻患者给予更多关注。IMPACT-III 问卷是一种可靠的工具，可用于测量意大利语儿童的 QoL。
