Sun A H, Xiao S Z, Zheng Z, Li B S, Li Z J, Wang T Y
Otolaryngological Laboratories, Changhai Hospital, Shanghai, China.
Acta Otolaryngol. 1987 Sep-Oct;104(3-4):211-6. doi: 10.3109/00016488709107320.
The effects of iron deficiency on the cochlea were studied in growing rats fed with a basic iron-deficient diet for 80 days. The electrophysiological changes (auditory thresholds raised more than 15 dB) were observed in 47% of the cochleas of iron-deficient rats. When these organs of Corti were examined by scanning electron microscopy, abnormalities of outer or inner hair cells were found, as follows: (1) fusion and torsion of the stereocilia, (2) coalescence of adjacent stereocilia in the same row, (3) loss of sensory hair stiffness, and (4) loss of stereocilia. Within each lesion, the neighbouring supporting cells and their microvilli showed no damage. The findings indicate that cochlear impairment can be induced by iron deficiency. The peroxidative mechanisms responsible for the lesions of stereocilia in iron deficiency are discussed.
在以缺铁基础饮食喂养80天的生长大鼠中研究了缺铁对耳蜗的影响。在47%的缺铁大鼠耳蜗中观察到电生理变化（听觉阈值升高超过15分贝）。当通过扫描电子显微镜检查这些柯蒂氏器时，发现外毛细胞或内毛细胞存在异常，如下：（1）静纤毛融合和扭转；（2）同一排相邻静纤毛合并；（3）感觉毛硬度丧失；（4）静纤毛缺失。在每个病变部位，相邻的支持细胞及其微绒毛未显示损伤。这些发现表明缺铁可诱发耳蜗损伤。本文讨论了缺铁时静纤毛损伤的过氧化机制。
