Department of Orthopaedics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.
J Wound Care. 2023 Feb 2;32(2):92-97. doi: 10.12968/jowc.2023.32.2.92.
To quantify the reduction in wound size and change in wound quality following low-cost topical oxygen therapy (TOT) in patients with acute traumatic musculoskeletal wounds of the foot and ankle.
This prospective interventional study included patients with acute traumatic musculoskeletal wounds of the foot and ankle of <3 weeks' duration after they had undergone debridement and required subsequent wound coverage. A sterile C-Arm cover was used to cover the wound and 100% oxygen was administered at 1 atm, at a rate of 10l/min for 90 minutes on each of four consecutive days, through a suction catheter connected to an oxygen cylinder. The cycle was repeated after a three-day break. Wound surface area (by plotting on graph paper) and wound quality (by modified wound infection checklist score and swabs for culture and Gram staining) were assessed before and after TOT application.
The study cohort included 20 patients ≥18 years of age. There was a statistically significant (p<0.001) reduction in mean wound surface area from 79.3cm at baseline to 69.6cm after two cycles of TOT. The mean modified wound infection checklist score was 13.6 and 0.8, respectively, before and after two cycles of TOT, suggesting statistically significant improvement (p=0.02) in wound quality. All patients showed no growth in their wound culture after TOT.
TOT appears to be a promising and cost-effective alternative in the management of traumatic wounds. However, future studies with larger sample sizes and control groups for comparison are needed to establish the benefit of TOT in acute traumatic musculoskeletal wounds.
定量评估低成本局部氧疗（TOT）对足部和踝关节急性创伤性肌肉骨骼伤口患者的伤口面积缩小和伤口质量变化。
这是一项前瞻性干预研究，纳入了足部和踝关节急性创伤性肌肉骨骼伤口的患者，这些伤口在清创后持续时间<3 周，需要进一步的伤口覆盖。使用无菌 C 臂罩覆盖伤口，在连续 4 天的每天 90 分钟内，以 10L/min 的速度通过连接到氧气罐的吸引导管向伤口内输送 100%氧气。在 3 天的休息后重复该循环。在 TOT 应用前后，通过绘制在方格纸上的方法评估伤口表面积（通过绘制在方格纸上的方法评估）和伤口质量（通过改良伤口感染检查表评分和培养及革兰氏染色的拭子评估）。
该研究队列包括 20 名年龄≥18 岁的患者。TOT 应用两个周期后，平均伤口面积从基线时的 79.3cm 显著减少到 69.6cm（p<0.001）。TOT 应用前后改良伤口感染检查表评分的平均值分别为 13.6 和 0.8，提示伤口质量有显著改善（p=0.02）。TOT 后所有患者的伤口培养均未见生长。
TOT 似乎是治疗创伤性伤口的一种有前途且具有成本效益的替代方法。然而，需要进行更大样本量和对照组的未来研究，以确定 TOT 在急性创伤性肌肉骨骼伤口中的益处。
