Kaufman Hanna, Gurevich Maxim, Tamir Eran, Keren Elad, Alexander Lipkin, Hayes Paul
Head of Department; 1Northern District Trauma & Wound Clinics Division, "Maccabi" Health Care Services.
Hillel Yaffe Medical Center.
J Wound Care. 2018 Jul 2;27(7):426-433. doi: 10.12968/jowc.2018.27.7.426.
Oxygen plays a central role in wound healing. Recent technological advances have miniaturised oxygen delivery systems, with novel topical oxygen therapy allowing patients to receive oxygen therapy 24 hours a day while remaining completely mobile. Here we aim to examine the efficacy and safety of continuous topical oxygen diffusion in a 'real-world' setting.
Topical oxygen therapy (TOT) was evaluated in patients with chronic, non-healing wounds in a tertiary referral specialist clinic.
The mean wound duration before TOT was 15 months. Regardless of treatment duration, in this previously non-healing group complete wound closure was observed in 32% of the total patients treated with the TOT device. However, optimal wound healing occurred when the device was used for >25 days, with an 83% wound area reduction and 47% wound closure rate seen in venous leg ulcers (VLUs) and a 74% reduction and a 57% wound closure rate in arterial foot ulcers.
Use of TOT in chronic wounds stimulates a healing state. In our study, almost half of the previously non-healing wounds closed.
氧气在伤口愈合中起着核心作用。最近的技术进步使氧气输送系统小型化，新型局部氧气疗法使患者能够在完全可活动的情况下每天24小时接受氧气治疗。在此，我们旨在研究在“现实世界”环境中持续局部氧气扩散的疗效和安全性。
在一家三级转诊专科诊所对慢性难愈合伤口患者进行局部氧气疗法（TOT）评估。
接受TOT治疗前伤口的平均持续时间为15个月。无论治疗时长如何，在这个先前难愈合的患者组中，使用TOT设备治疗的所有患者中有32%实现了伤口完全闭合。然而，当该设备使用超过25天时，伤口实现最佳愈合，静脉性腿部溃疡（VLUs）的伤口面积减少83%，伤口闭合率为47%；动脉性足部溃疡的伤口面积减少74%，伤口闭合率为57%。
在慢性伤口中使用TOT可促进愈合状态。在我们的研究中，几乎一半先前难愈合的伤口实现了闭合。
