Hillerdal M, Jansson B, Engström B, Hultcrantz E, Borg E
Department of Oto-Rhino-Laryngology, University Hospital, Stockholm, Sweden.
Acta Otolaryngol. 1987 Sep-Oct;104(3-4):270-8. doi: 10.3109/00016488709107328.
Cochlear blood flow was measured in rats with a known noise-induced hearing loss, using the microsphere technique. The animals were exposed to simulated industrial noise for 3 months. The rats were divided into four groups: young and old; normotensive (N) and spontaneously hypertensive (SH). The mean values of the cochlear blood flows were compared with those of rats from matched groups not exposed to noise. The mean cochlear blood flow in the noise-exposed groups was lower than in the non-exposed groups. The decrease in cochlear blood flow was significant for all groups except young SH rats and was more pronounced in the older age group. Cochleas from the groups of old N and SH rats were investigated in the scanning electron microscope. Extensive changes were far more common in SH than in N rats.
采用微球技术测量了已知患有噪声性听力损失的大鼠的耳蜗血流量。这些动物暴露于模拟工业噪声中3个月。大鼠被分为四组：年轻和年老；正常血压（N）和自发性高血压（SH）。将耳蜗血流量的平均值与未暴露于噪声的匹配组大鼠的平均值进行比较。噪声暴露组的平均耳蜗血流量低于未暴露组。除年轻SH大鼠外，所有组的耳蜗血流量均显著下降，且在老年组中更为明显。对老年N组和SH组大鼠的耳蜗进行了扫描电子显微镜检查。与N组大鼠相比，SH组大鼠的广泛变化更为常见。
