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观察肌醇三磷酸受体中的钙结合位点。

Viewing Ca-binding sites in the inositol trisphosphate receptor.

机构信息

Department of Physiology, Perelman School of Medicine, University of Pennsylvania, 700D Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA.

Department of Physiology, Perelman School of Medicine, University of Pennsylvania, 700D Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA.

出版信息

Cell Calcium. 2023 Mar;110:102697. doi: 10.1016/j.ceca.2023.102697. Epub 2023 Jan 27.

DOI:10.1016/j.ceca.2023.102697
PMID:36736164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10173365/
Abstract

Ca is a major ligand of the inositol 1,4,5-trisphosphate receptor (IPR) Ca-release channel. Fan et al. [1] recently solved additional cryo-electron microscopy (cryo-EM) structures of the IPR in different ligand-binding states, revealing new Ca binding sites.

摘要

钙是肌醇 1,4,5-三磷酸受体（IPR）钙释放通道的主要配体。范等人。[1] 最近解决了不同配体结合状态下 IPR 的额外冷冻电子显微镜（cryo-EM）结构，揭示了新的钙结合位点。

相似文献

1
Viewing Ca-binding sites in the inositol trisphosphate receptor.观察肌醇三磷酸受体中的钙结合位点。
Cell Calcium. 2023 Mar;110:102697. doi: 10.1016/j.ceca.2023.102697. Epub 2023 Jan 27.
2
Structural and functional conservation of the activating Ca binding site in inositol 1,4.5-trisphosphate and ryanodine receptors.在肌醇 1,4,5-三磷酸和兰尼碱受体中激活 Ca 结合位点的结构和功能保守性。
Cell Calcium. 2022 Dec;108:102671. doi: 10.1016/j.ceca.2022.102671. Epub 2022 Nov 5.
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Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist.人源三磷酸肌醇受体 3 型冷冻电镜结构揭示了一种作为拮抗剂的自身结合肽的存在。
J Biol Chem. 2020 Feb 7;295(6):1743-1753. doi: 10.1074/jbc.RA119.011570. Epub 2020 Jan 8.
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Structural basis for activation and gating of IP receptors.IP 受体的激活和门控的结构基础。
Nat Commun. 2022 Mar 17;13(1):1408. doi: 10.1038/s41467-022-29073-2.
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Conformational motions and ligand-binding underlying gating and regulation in IPR channel.IPR 通道门控和调节的构象运动和配体结合。
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Understanding IPR channels: From structural underpinnings to ligand-dependent conformational landscape.理解 IPR 通道：从结构基础到配体依赖的构象景观。
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Structural basis for the regulation of inositol trisphosphate receptors by Ca and IP.钙和 IP 调节肌醇三磷酸受体的结构基础。
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Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function.疾病相关突变会影响肌醇 1,4,5-三磷酸受体亚基的通道功能。
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Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors.钙结合位点在肌醇 1,4,5-三磷酸受体激活中的功能鉴定。
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本文引用的文献

1
Conformational motions and ligand-binding underlying gating and regulation in IPR channel.IPR 通道门控和调节的构象运动和配体结合。
Nat Commun. 2022 Nov 14;13(1):6942. doi: 10.1038/s41467-022-34574-1.
2
Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors.钙结合位点在肌醇 1,4,5-三磷酸受体激活中的功能鉴定。
Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2209267119. doi: 10.1073/pnas.2209267119. Epub 2022 Sep 19.
3
Structural basis for activation and gating of IP receptors.IP 受体的激活和门控的结构基础。
Nat Commun. 2022 Mar 17;13(1):1408. doi: 10.1038/s41467-022-29073-2.
4
Calcium-release channels: structure and function of IP receptors and ryanodine receptors.钙释放通道：肌醇1,4,5-三磷酸受体和兰尼碱受体的结构与功能
Physiol Rev. 2022 Jan 1;102(1):209-268. doi: 10.1152/physrev.00033.2020. Epub 2021 Jul 19.
5
Structural basis for the regulation of inositol trisphosphate receptors by Ca and IP.钙和 IP 调节肌醇三磷酸受体的结构基础。
Nat Struct Mol Biol. 2018 Aug;25(8):660-668. doi: 10.1038/s41594-018-0089-6. Epub 2018 Jul 16.
6
Ryanodine receptor resolution revolution: Implications for InsP receptors?兰尼碱受体解析的变革：对肌醇磷酸受体有何影响？
Cell Calcium. 2017 Jan;61:53-56. doi: 10.1016/j.ceca.2016.11.002. Epub 2016 Nov 6.
7
Inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum: A single-channel point of view.内质网中的肌醇1,4,5-三磷酸受体：单通道视角
Cell Calcium. 2015 Jul;58(1):67-78. doi: 10.1016/j.ceca.2014.12.008. Epub 2014 Dec 18.
8
Regulation of IP(3)R Channel Gating by Ca(2+) and Ca(2+) Binding Proteins.Ca(2+)和Ca(2+)结合蛋白对IP(3)R通道门控的调节
Curr Top Membr. 2010;66:235-72. doi: 10.1016/S1063-5823(10)66011-5. Epub 2010 Jul 25.
9
Inositol trisphosphate receptor Ca2+ release channels.肌醇三磷酸受体钙离子释放通道
Physiol Rev. 2007 Apr;87(2):593-658. doi: 10.1152/physrev.00035.2006.
10
Novel regulation of calcium inhibition of the inositol 1,4,5-trisphosphate receptor calcium-release channel.肌醇1,4,5-三磷酸受体钙释放通道钙抑制的新型调控
J Gen Physiol. 2003 Nov;122(5):569-81. doi: 10.1085/jgp.200308808.