观察肌醇三磷酸受体中的钙结合位点。
Viewing Ca-binding sites in the inositol trisphosphate receptor.
机构信息
Department of Physiology, Perelman School of Medicine, University of Pennsylvania, 700D Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA.
Department of Physiology, Perelman School of Medicine, University of Pennsylvania, 700D Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA.
出版信息
Cell Calcium. 2023 Mar;110:102697. doi: 10.1016/j.ceca.2023.102697. Epub 2023 Jan 27.
Abstract
Ca is a major ligand of the inositol 1,4,5-trisphosphate receptor (IPR) Ca-release channel. Fan et al. [1] recently solved additional cryo-electron microscopy (cryo-EM) structures of the IPR in different ligand-binding states, revealing new Ca binding sites.
摘要
钙是肌醇 1,4,5-三磷酸受体（IPR）钙释放通道的主要配体。范等人。[1] 最近解决了不同配体结合状态下 IPR 的额外冷冻电子显微镜（cryo-EM）结构，揭示了新的钙结合位点。
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本文引用的文献
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Conformational motions and ligand-binding underlying gating and regulation in IPR channel.IPR 通道门控和调节的构象运动和配体结合。
Nat Commun. 2022 Nov 14;13(1):6942. doi: 10.1038/s41467-022-34574-1.
2
Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors.钙结合位点在肌醇 1,4,5-三磷酸受体激活中的功能鉴定。
Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2209267119. doi: 10.1073/pnas.2209267119. Epub 2022 Sep 19.
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Structural basis for activation and gating of IP receptors.IP 受体的激活和门控的结构基础。
Nat Commun. 2022 Mar 17;13(1):1408. doi: 10.1038/s41467-022-29073-2.
4
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Physiol Rev. 2022 Jan 1;102(1):209-268. doi: 10.1152/physrev.00033.2020. Epub 2021 Jul 19.
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