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Emerging role of mitochondrial calcium levels in cellular senescence and in switching cell fates.

作者信息

Margand Céline, Morgado-Cáceres Pablo, Ahumada-Castro Ulises, Cárdenas J César, Martin Nadine, Bernard David

机构信息

Cellular Senescence, Cancer & Aging team, Cancer Research Center of Lyon, INSERM U1052, CNRS UMR 5286, Centre Léon Bérard, Université Claude Bernard Lyon 1, South-ROCK Consortium, Institut Convergence Plascan, Lyon, France.

Equipe Labellisée la Ligue Contre le Cancer, Lyon, France.

出版信息

Nat Aging. 2025 May 26. doi: 10.1038/s43587-025-00887-1.

DOI:10.1038/s43587-025-00887-1
PMID:40419804
Abstract
摘要

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本文引用的文献

1
Cyclophilin D plays a critical role in the survival of senescent cells.亲环素D在衰老细胞的存活中起关键作用。
EMBO J. 2024 Dec;43(23):5972-6000. doi: 10.1038/s44318-024-00259-2. Epub 2024 Oct 24.
2
Elimination of damaged mitochondria during UVB-induced senescence is orchestrated by NIX-dependent mitophagy.UVB 诱导衰老过程中受损线粒体的消除是由 NIX 依赖性的线粒体自噬所调控的。
Aging Cell. 2024 Aug;23(8):e14186. doi: 10.1111/acel.14186. Epub 2024 May 17.
3
Converting cell death into senescence by PARP1 inhibition improves recovery from acute oxidative injury.
通过 PARP1 抑制将细胞死亡转化为衰老可改善急性氧化损伤的恢复。
Nat Aging. 2024 Jun;4(6):771-782. doi: 10.1038/s43587-024-00627-x. Epub 2024 May 9.
4
Apoptotic stress causes mtDNA release during senescence and drives the SASP.细胞衰老过程中的凋亡应激导致线粒体 DNA 释放,并驱动 SASP。
Nature. 2023 Oct;622(7983):627-636. doi: 10.1038/s41586-023-06621-4. Epub 2023 Oct 11.
5
Regulation and role of calcium in cellular senescence.钙在细胞衰老中的调节和作用。
Cell Calcium. 2023 Mar;110:102701. doi: 10.1016/j.ceca.2023.102701. Epub 2023 Jan 27.
6
Capture at the ER-mitochondrial contacts licenses IP receptors to stimulate local Ca transfer and oxidative metabolism.在急诊室捕获线粒体接触点可使 IP 受体获得许可,从而刺激局部 Ca 转移和氧化代谢。
Nat Commun. 2022 Nov 9;13(1):6779. doi: 10.1038/s41467-022-34365-8.
7
Cellular senescence: all roads lead to mitochondria.细胞衰老:条条大路通线粒体。
FEBS J. 2023 Mar;290(5):1186-1202. doi: 10.1111/febs.16361. Epub 2022 Jan 30.
8
Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging.钙离子通道 ITPR2 和线粒体-内质网接触促进细胞衰老和老化。
Nat Commun. 2021 Feb 1;12(1):720. doi: 10.1038/s41467-021-20993-z.
9
Enhanced inter-compartmental Ca flux modulates mitochondrial metabolism and apoptotic threshold during aging.增强细胞间隙钙流调节衰老过程中线粒体代谢和凋亡阈值。
Redox Biol. 2019 Jan;20:458-466. doi: 10.1016/j.redox.2018.11.003. Epub 2018 Nov 9.
10
Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria.通过抑制钙离子从内质网向线粒体的转移实现癌细胞的选择性易损性
Cell Rep. 2016 Apr 5;15(1):219-220. doi: 10.1016/j.celrep.2016.03.045.