Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No.36 Sanhao Street, Shenyang, Liaoning Province, China.
Biomed Pharmacother. 2023 Apr;160:114314. doi: 10.1016/j.biopha.2023.114314. Epub 2023 Feb 2.
LncRNAs are involved in many physiological and pathological processes, including chromatin remodeling, transcription, posttranscriptional gene expression, mRNA stability, translation, and posttranslational modification, and their functions depend on subcellular localization. MIR503HG is a lncRNA as well as a host gene for the miRNAs miR-503 and miR-424. MIR503HG functions independently or synergistically with miR-503. MIR503HG affects cell proliferation, invasion, metastasis, apoptosis, angiogenesis, and other biological behaviors. The mechanism of MIR503HG in disease includes interaction with protein, sponging miRNA to regulate downstream target gene, and participation in NF-κB, TGF-β, ERK/MAPK, and PI3K/AKT signaling pathways. In this review, we summarize the molecular mechanisms of MIR503HG in disease and its potential applications in diagnosis, prognosis, and treatment. We also raise some unanswered questions in this area, providing insights for future research.
lncRNAs 参与许多生理和病理过程，包括染色质重塑、转录、转录后基因表达、mRNA 稳定性、翻译和翻译后修饰，其功能取决于亚细胞定位。MIR503HG 是一种 lncRNA，也是 miRNA miR-503 和 miR-424 的宿主基因。MIR503HG 与 miR-503 独立或协同发挥作用。MIR503HG 影响细胞增殖、侵袭、转移、凋亡、血管生成和其他生物学行为。MIR503HG 在疾病中的机制包括与蛋白质相互作用、海绵吸附 miRNA 以调节下游靶基因，以及参与 NF-κB、TGF-β、ERK/MAPK 和 PI3K/AKT 信号通路。在这篇综述中，我们总结了 MIR503HG 在疾病中的分子机制及其在诊断、预后和治疗中的潜在应用。我们还提出了该领域的一些未解决问题，为未来的研究提供了思路。
