Delberghe X, Charles G, Uytdenhoef P, Jacquy J, Wilmotte J
Service de psychiatrie de l'Hôpital Civil de Charleroi.
Acta Psychiatr Belg. 1987 May-Jun;87(3):346-52.
In this case report, we observed a delirium probably owing to toxic effects of homatropine eye drops. We reproduced this syndrome and we reversed it with physostigmine salicylate as an antidote. We observed a decrease of cortisol at 9.00 a.m. and impairment of regional cerebral blood flow with increase in the previous right side. The unusual susceptibility of this patient to the anticholinergic effect of homatropine is perhaps related to a preexisting mild cognitive defect possibly related to a cholinergic neurotransmitter deficit.
在本病例报告中，我们观察到一例谵妄，可能是由于后马托品眼药水的毒性作用所致。我们重现了这一综合征，并使用水杨酸毒扁豆碱作为解毒剂将其逆转。我们观察到上午9点时皮质醇水平下降，以及局部脑血流量受损，且之前右侧脑血流量增加。该患者对后马托品的抗胆碱能作用异常敏感，可能与先前存在的轻度认知缺陷有关，而这种缺陷可能与胆碱能神经递质缺乏有关。
