Falsarella Priscila Mina, Nasser Felipe, Affonso Breno Boueri, Galastri Francisco Leonardo, Motta-Leal-Filho Joaquim Mauricio da, Valle Leonardo Guedes Moreira, Cunha Marcela Juliano Silva, Araújo Sergio Eduardo Alonso, Garcia Rodrigo Gobbo, Katz Marcelo
Center of Interventional Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil; Interventional Radiology, Hospital Municipal Vila Santa Catarina Dr Gilson de Cassia Marques de Carvalho, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Center of Interventional Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
J Vasc Interv Radiol. 2023 May;34(5):736-744.e1. doi: 10.1016/j.jvir.2023.01.022. Epub 2023 Jan 31.
To compare short-term and medium-term results of superior rectal artery embolization versus surgical hemorrhoidectomy in the treatment of patients with hemorrhoidal disease.
This study was a prospective randomized clinical trial following 33 patients with symptomatic hemorrhoidal disease Grades 2 and 3 who were randomly assigned to 2 different groups: the superior rectal artery embolization group (n = 15) and Ferguson closed hemorrhoidectomy surgical group (n = 14). Four patients were excluded from the analysis. Pain using the visual analog scale and the use of analgesics were evaluated 3 times daily during the first 7 days of the postoperative period. Recurrent symptoms and satisfaction with treatment were also evaluated in the subsequent first, third, sixth, and twelfth months.
The mean pain during the first bowel movement after the procedure was 6.08 ± 4.41 in the surgery group and 0 in the embolization group (P = .001). The mean use of pain medication was higher in the surgery group (28.92 doses ± 15.78 vs 2.4 doses ± 5.21; P < .001). In the embolization group, the most prevalent preprocedural symptom was bleeding in 14 patients, with complete improvement in 12 (83.3%) patients. Mucus, skin tag, and pruritus were symptoms that showed little improvement in both groups. The frequency of symptoms (bleeding, pain, prolapse, and pruritus) was similar between the groups at 12 months (P = .691). No severe adverse events were observed in both groups.
Despite no difference in outcomes, embolization of the superior rectal arteries for the treatment of hemorrhoidal disease showed pain levels lower than those observed after surgical treatment.
比较直肠上动脉栓塞术与手术痔切除术治疗痔病患者的短期和中期结果。
本研究为前瞻性随机临床试验,纳入33例有症状的2级和3级痔病患者,随机分为2组:直肠上动脉栓塞组(n = 15)和弗格森闭合痔切除术手术组(n = 14)。4例患者被排除在分析之外。术后第1个7天,每天3次使用视觉模拟量表评估疼痛情况以及镇痛药的使用情况。在随后的第1、3、6和12个月还评估了复发症状和治疗满意度。
术后首次排便时,手术组的平均疼痛评分为6.08±4.41,而栓塞组为0(P = .001)。手术组的平均镇痛药使用量更高(28.92剂±15.78 vs 2.4剂±5.21;P < .001)。在栓塞组中,术前最常见的症状是14例患者出血,其中12例(83.3%)患者完全改善。黏液、皮赘和瘙痒在两组中改善甚微。两组在12个月时症状(出血、疼痛、脱垂和瘙痒)的发生频率相似(P = .691)。两组均未观察到严重不良事件。
尽管治疗效果无差异,但直肠上动脉栓塞术治疗痔病的疼痛程度低于手术治疗后的疼痛程度。