Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwig-Guttmann-Strasse 13, 67071 Ludwigshafen/Rhine, Germany.
Carbohydr Polym. 2023 Apr 1;305:120555. doi: 10.1016/j.carbpol.2023.120555. Epub 2023 Jan 6.
Chitosan (CS) and its derivatives have been applied extensively in the biomedical field owing to advantageous characteristics including biodegradability, biocompatibility, antibacterial activity and adhesive properties. The low solubility of CS at physiological pH limits its use in systems requiring higher dissolving ability and a suitable drug release rate. Besides, CS can result in fast drug release because of its high swelling degree and rapid water absorption in aqueous media. As a water-soluble derivative of CS, carboxymethyl chitosan (CMC) has certain improved properties, rendering it a more suitable candidate for wound healing, drug delivery and tissue engineering applications. This review will focus on the antibacterial, anticancer and antitumor, antioxidant and antifungal bioactivities of CMC and the most recently described applications of CMC in wound healing, drug delivery, tissue engineering, bioimaging and cosmetics.
壳聚糖（CS）及其衍生物由于具有生物降解性、生物相容性、抗菌活性和粘附性等优点，已广泛应用于生物医学领域。CS 在生理 pH 值下的低溶解度限制了其在需要更高溶解能力和合适药物释放率的系统中的应用。此外，CS 由于在水介质中具有高溶胀度和快速吸水性，会导致药物快速释放。作为 CS 的水溶性衍生物，羧甲基壳聚糖（CMC）具有某些改善的性能，使其更适合用于伤口愈合、药物输送和组织工程应用。本综述将重点介绍 CMC 的抗菌、抗癌和抗肿瘤、抗氧化和抗真菌生物活性，以及最近描述的 CMC 在伤口愈合、药物输送、组织工程、生物成像和化妆品中的应用。
