The Department of Plastic, Burn and Maxillofacial Surgery, Faculty of Medicine, Ain- Shams University, Cairo, Egypt.
Asian J Surg. 2023 Sep;46(9):3627-3633. doi: 10.1016/j.asjsur.2023.01.097. Epub 2023 Feb 1.
chronic wounds represent a challenge in treatment, due to diverse pathogenesis, resistance to ordinary treatment complex and lack of direct methods of treatment In this study, the aim is to compare the effect of Platelet -rich plasma (PRP) and mechanically emulsified fat grafts on the outcome of the healing process of chronic wounds.
In the current study, 30 patients with chronic wounds were divided into two groups (Group I, 15 patients had application of PRP on chronic wounds). Whereas (Group II, 15 patients had application of mechanically emulsified fat on chronic wounds). In both groups assessment of the healing rates and histopathological changes that were determined by observing the parameters of wound healing, including peri-lesional skin quality, observation of the wound size and depth, assessment of the pain indicated by Visual analog scale score.
Patient were followed up for 6 months. Group II showed a better healing rate 64% in comparison to Group I 55%. Wound parameters and pain score were recorded in both groups with no statistically significant difference.
Both PRP and mechanically emulsified fat grafts were found to be efficient treatment modalities in management of chronic "non-healing" wounds. But mechanically emulsified fat grafts represent a better treatment method for chronic wounds.
慢性创面的治疗极具挑战性，这是由于其发病机制多样，普通治疗方法效果不佳且缺乏直接的治疗方法。本研究旨在比较富血小板血浆（PRP）和机械乳化脂肪移植物对慢性创面愈合过程结局的影响。
在目前的研究中，将 30 例慢性创面患者分为两组（I 组 15 例患者应用 PRP 于慢性创面，II 组 15 例患者应用机械乳化脂肪于慢性创面）。在两组中，评估愈合率和组织病理学变化，通过观察创面愈合的参数来确定，包括围病变皮肤质量、观察创面大小和深度、视觉模拟评分法评估疼痛。
患者随访 6 个月。II 组的愈合率为 64%，优于 I 组的 55%。两组均记录了创面参数和疼痛评分，但无统计学差异。
PRP 和机械乳化脂肪移植物均被发现是治疗慢性“不愈合”创面的有效方法，但机械乳化脂肪移植物是治疗慢性创面的更好方法。
