Faculty of Electrical and Computer Engineering, University of Tabriz, Tabriz, 5166616471, Iran.
Sci Rep. 2023 Feb 3;13(1):1975. doi: 10.1038/s41598-023-29122-w.
This work proposes a novel design composed of graphene nanoribbons-based optofluidic tweezers to manipulate and sort bio-particles with radii below 2.5 nm. The suggested structure has been numerically investigated by the finite difference time domain (FDTD) method employing Maxwell's stress tensor analysis (MST). The finite element method (FEM) has been used to obtain the electrostatic response of the proposed structure. The tweezer main path is a primary channel in the center of the structure, where the microfluidic flow translates the nanoparticle toward this channel. Concerning the microfluid's drag force, the nanoparticles tend to move along the length of the main channel. The graphene nanoribbons are fixed near the main channel at different distances to exert optical forces on the moving nanoparticles in the perpendicular direction. In this regard, sub-channels embedding in the hBN layer on the Si substrate deviate bio-particles from the main path for particular nanoparticle sizes and indices. Intense hotspots with electric field enhancements up to 900 times larger than the incident light are realized inside and around the graphene ribbons. Adjusting the gap distance between the graphene nanoribbon and the main channel allows us to separate the individual particle with a specific size from others, thus guiding that in the desired sub-channel. Furthermore, we demonstrated that in a structure with a large gap between channels, particles experience weak field intensity, leading to a low optical force that is insufficient to detect, trap, and manipulate nanoparticles. By varying the chemical potential of graphene associated with the electric field intensity variations in the graphene ribbons, we realized tunability in sorting nanoparticles while structural parameters remained constant. In fact, by adjusting the graphene Fermi level via the applied gate voltage, nanoparticles with any desired radius will be quickly sorted. Moreover, we exhibited that the proposed structure could sort nanoparticles based on their refractive indices. Therefore, the given optofluidic tweezer can easily detect bio-particles, such as cancer cells and viruses of tiny size.
这项工作提出了一种由石墨烯纳米带构成的新型光流镊子设计,用于操纵和分类半径小于 2.5nm 的生物颗粒。所提出的结构已经通过有限差分时间域(FDTD)方法进行了数值研究,采用了麦克斯韦应力张量分析(MST)。有限元方法(FEM)已用于获得所提出结构的静电响应。镊子的主路径是结构中心的一个主要通道,微流体流动将纳米颗粒推向该通道。关于微流体的阻力,纳米颗粒倾向于沿主通道的长度移动。石墨烯纳米带固定在主通道附近的不同距离处,以便在垂直方向上对移动的纳米颗粒施加光力。在这方面,嵌入 Si 衬底上 hBN 层中的亚通道会使生物颗粒偏离主路径,对于特定的纳米颗粒尺寸和折射率。在石墨烯带内部和周围实现了高达入射光 900 倍的强电场增强热点。调整石墨烯纳米带与主通道之间的间隙距离,我们可以将具有特定尺寸的单个颗粒与其他颗粒分离,从而引导它们进入所需的亚通道。此外,我们证明,在通道之间具有较大间隙的结构中,颗粒经历较弱的场强,导致光力不足,不足以检测、捕获和操纵纳米颗粒。通过改变与石墨烯带中电场强度变化相关的石墨烯化学势,我们实现了在结构参数保持不变的情况下对纳米颗粒进行分选的可调性。事实上,通过调整施加栅极电压的石墨烯费米能级,可以快速对具有任何所需半径的纳米颗粒进行分类。此外,我们展示了所提出的结构可以基于它们的折射率对纳米颗粒进行分类。因此,所给出的光流镊子可以轻松检测生物颗粒,如小尺寸的癌细胞和病毒。