Department of Orthopaedic Surgery, the Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Mathematics and Statistics School, Central South University, Changsha, 410000, Hunan, China.
BMC Geriatr. 2023 Feb 3;23(1):72. doi: 10.1186/s12877-022-03710-3.
Chromium (Cr) and cobalt (Co) are the essential elements for producing metal implants, but might have potential health issues. The research on the correlation between metal implants and blood Cr and Co on a large population is still limited.
National Health and Nutrition Examination Survey (NHANES) is a program of studies designed to assess the health status of Americans began in the early 1960s. The study was based on the NHANES database from two data collection years (2015-2016 and 2017-2018). The exposure variable of this study was whether the participants had metal objects in the body or not. The outcome variables were blood concentrations of Cr and Co. Age, body mass index, sex, race/ethnicity, income to poverty ratio, tap water behavior, shellfish/fish/tuna/salmon eating habits, level of education, smoking behavior, marital status, blood hemoglobin, and data collection years were included as confounding variables.
A total of 4412 participants, aged 40 years or older, were included in this analysis, consisting of the without metal objects group (n = 3150) and the metal objects group (n = 1262). Metal objects was positively correlated to the accumulation of blood Cr (β = 0.072, 95% CI: 0.043-0.102, p < 0.001) and blood Co (β = 0.079, 95% CI: 0.049-0.109, p < 0.001). However, the positive correlation of metal objects with blood Cr was only presented in women (β = 0.112, 95% CI: 0.074-0.151, p < 0.001), but not in men. Meanwhile, the positive relationship between metal objects and blood Cr/Co was not observed in the Asian subgroup.
Blood Cr and Co concentrations were statistically higher in people with metal objects, but with race and sex differences.
Level IV, cross-sectional study.
铬（Cr）和钴（Co）是生产金属植入物的必需元素，但可能存在潜在的健康问题。关于大量人群中金属植入物与血液 Cr 和 Co 之间的相关性的研究仍然有限。
国家健康和营养检查调查（NHANES）是一项始于 20 世纪 60 年代的评估美国人健康状况的研究计划。本研究基于 NHANES 数据库中两个数据收集年份（2015-2016 年和 2017-2018 年）的数据。本研究的暴露变量是参与者体内是否有金属物体。因变量是血液 Cr 和 Co 的浓度。年龄、体重指数、性别、种族/民族、收入与贫困比例、自来水行为、贝类/鱼类/金枪鱼/三文鱼饮食习惯、受教育程度、吸烟行为、婚姻状况、血红蛋白以及数据收集年份被纳入混杂变量。
本分析共纳入 4412 名年龄在 40 岁及以上的参与者，包括无金属物体组（n=3150）和金属物体组（n=1262）。金属物体与血液 Cr 的积累呈正相关（β=0.072，95%置信区间：0.043-0.102，p<0.001）和血液 Co（β=0.079，95%置信区间：0.049-0.109，p<0.001）。然而，金属物体与血液 Cr 之间的正相关关系仅见于女性（β=0.112，95%置信区间：0.074-0.151，p<0.001），而在男性中则不然。同时，在亚裔亚组中没有观察到金属物体与血液 Cr/Co 之间的正相关关系。
金属物体人群的血液 Cr 和 Co 浓度统计上更高，但存在种族和性别差异。
IV 级，横断面研究。
