Beijing Technology and Business University, Beijing 100048, China; Beijing Engineering and Technology Research Center of Food Additives, Beijing 100048, China.
Beijing Technology and Business University, Beijing 100048, China; Beijing Engineering and Technology Research Center of Food Additives, Beijing 100048, China.
Food Res Int. 2023 Feb;164:112362. doi: 10.1016/j.foodres.2022.112362. Epub 2022 Dec 28.
Rosa rugosa cv. Plena is a 'drug homologous food' in China with a long history. Pingyin rose essential oil (PREO) is a mixture of compounds extracted from blooming R. rugosa cv. Plena. With its elegant smell and excellent effects on oxidative stress and inflammation alleviation, PREO is wildly used in the food industry as a popular additive. We aimed to decipher if the PREO could alleviate and restore dextran sodium sulfate (DSS)-induced barrier integrity damages. The results showed that a 7-day PREO (15 μL/kg) treatment alleviated the colitis symptoms by improving disease activity index (DAI) scores through weight loss, occult blood, and colon shortening. The expression of tight junction proteins and the enzyme activities of superoxide dismutases (SOD), and catalase (CAT) increased while nitric oxide (NO), malondialdehyde (MDA), and myeloperoxidase (MPO) production decreased in PREO-treated C57BL6 female mice. PREO treatment inhibited the expression of pro-inflammatory cytokines tumor necrosis factor (TNF-α), interleukin (IL)-1β, and IL-6. Further, PREO modulated the composition of the gut microbiota and Spearman's correlation analysis revealed a positive effect. The transcriptome analysis and western blot results indicated that PREO might ameliorate intestinal barrier dysfunction in this study via the TLR4-NF-kB signaling pathway. We hypothesized that PREO has preventive potential against gut disorders and could serve as a functional food additive.
平阴玫瑰精油（PREO）是从盛开的重瓣玫瑰中提取的化合物混合物。PREO 气味优雅，对缓解氧化应激和炎症具有出色的效果，因此在食品工业中被广泛用作流行的添加剂。我们旨在研究 PREO 是否可以减轻和修复葡聚糖硫酸钠（DSS）诱导的屏障完整性损伤。结果表明，7 天 PREO（15μL/kg）治疗通过减轻体重减轻、隐血和结肠缩短，通过降低疾病活动指数（DAI）评分来减轻结肠炎症状。紧密连接蛋白的表达和超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的酶活性增加，而一氧化氮（NO）、丙二醛（MDA）和髓过氧化物酶（MPO）的产生减少。PREO 处理抑制了促炎细胞因子肿瘤坏死因子（TNF-α）、白细胞介素（IL）-1β和 IL-6 的表达。此外，PREO 调节了肠道微生物群的组成，Spearman 相关分析显示出积极的影响。转录组分析和 Western blot 结果表明，PREO 可能通过 TLR4-NF-κB 信号通路改善本研究中的肠道屏障功能障碍。我们假设 PREO 具有预防肠道紊乱的潜力，并可以作为功能性食品添加剂。
