Baizabal-Carvallo José Fidel, Jankovic Joseph
Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA; Department of Sciences and Engineering, University of Guanajuato, León, Mexico.
Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
J Neurol Sci. 2023 Mar 15;446:120577. doi: 10.1016/j.jns.2023.120577. Epub 2023 Feb 1.
Secondary dystonia has been associated with diverse etiologies. Dystonia associated with brain tumors has not been well characterized.
To characterize dystonia and relationship with parenchymal brain tumors.
We present six patients (1.03%) with dystonia related to parenchymal brain tumors, among 580 screened cases.
Contralateral hemidystonia was observed in four cases, followed by focal limb (n = 1) and cervical dystonia (n = 1). Dystonia presented during the phase of tumor growth in four cases, and following tumor treatment in two, one case had re-emergent dystonia. Tumors were low-grade (WHO I or II) and located in the basal ganglia (n = 3), cortical areas (n = 2), thalamus (n = 1) and cerebral peduncle (n = 1).
Secondary dystonia may be caused by brain tumors in diverse locations including basal ganglia, cortex and thalamus. It may be the presenting symptom of brain tumor or follow surgical resection combined with ancillary therapy.
继发性肌张力障碍与多种病因相关。与脑肿瘤相关的肌张力障碍尚未得到充分描述。
描述肌张力障碍及其与实质性脑肿瘤的关系。
在580例筛查病例中，我们报告了6例（1.03%）与实质性脑肿瘤相关的肌张力障碍患者。
4例观察到对侧半身肌张力障碍，其次是局灶性肢体肌张力障碍（n = 1）和颈部肌张力障碍（n = 1）。4例肌张力障碍出现在肿瘤生长阶段，2例出现在肿瘤治疗后，1例出现复发性肌张力障碍。肿瘤为低级别（世界卫生组织I级或II级），位于基底神经节（n = 3）、皮质区域（n = 2）、丘脑（n = 1）和脑桥（n = 1）。
继发性肌张力障碍可能由包括基底神经节、皮质和丘脑在内的不同部位的脑肿瘤引起。它可能是脑肿瘤的首发症状，或出现在手术切除联合辅助治疗之后。
