Kostić V S, Stojanović-Svetel M, Kacar A
Institute for Neurology CCS, Belgrade, Yugoslavia.
Can J Neurol Sci. 1996 Feb;23(1):53-6. doi: 10.1017/s0317167100039184.
Symptomatic (secondary) dystonias associated isolated lesions in the brain provide insight into etiopathogenesis of the idiopathic form of dystonia and are a basis for establishing the possible correlation between the anatomy of a lesion and the type of dystonia according to muscles affected.
In 358 patients with differently distributed dystonias, a group of 16 patients (4.5%) was encountered in whom dystonia was associated with focal brain lesions.
Of the 16 patients, 3 patients had generalized, 3 segmental and 4 hemidystonia, while the remaining 6 patients had focal dystonia. The most frequent etiologies were infarction in 7, and tumor in 4 patients. These lesions were usually found in the lenticular and caudate nucleus, thalamus, and in the case of blepharospasm in the upper brainstem.
Our results support the suggestion that dystonia is caused by a dysfunction of the basal ganglia.
与脑部孤立性病变相关的症状性（继发性）肌张力障碍有助于深入了解特发性肌张力障碍的病因发病机制，并且是根据受影响的肌肉来确定病变解剖结构与肌张力障碍类型之间可能相关性的基础。
在358例肌张力障碍分布不同的患者中，发现有16例（4.5%）患者的肌张力障碍与局灶性脑病变有关。
16例患者中，3例为全身性肌张力障碍，3例为节段性肌张力障碍，4例为偏侧肌张力障碍，其余6例为局限性肌张力障碍。最常见的病因是7例梗死和4例肿瘤。这些病变通常见于豆状核、尾状核、丘脑，而在眼睑痉挛患者中则见于上脑干。
我们的结果支持肌张力障碍是由基底神经节功能障碍引起的这一观点。
