Qiu Shanhu, Cai Xue, Liang Yan, Chen Wenji, Wang Duolao, Sun Zilin, Xie Bo, Wu Tongzhi
Department of General Practice, Zhongda Hospital; Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China; Research and Education Centre of General Practice, Zhongda Hospital, Southeast University, Nanjing, China.
Department of Nursing Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Diabetes Res Clin Pract. 2023 Mar;197:110562. doi: 10.1016/j.diabres.2023.110562. Epub 2023 Feb 3.
Previous studies assessing the association of muscle strength with risk of diabetes have seldomly accounted for the cumulative exposure over time. This study examined the association of 4-year cumulative muscle strength with risk of diabetes in middle-aged and older adults.
We included participants without diabetes, who had 3 repeated measurements of muscle strength, which was assessed by grip strength (normalized by body-weight) and chair-rising time, over 4 years. Cumulative muscle strength was calculated based on trapezoid rule. Logistic regression analysis and mediation analysis for cumulative blood pressure were performed.
We included 3731 and 3799 participants with data on cumulative grip strength and cumulative chair-rising time, respectively. The odds of diabetes were gradually reduced with increments in cumulative grip strength or decrements in cumulative chair-rising time, with the corresponding odds ratio being 0.79 and 0.89 per 1 standard deviation change after multivariable-adjustment. Cumulative systolic blood pressure mediated 10.8% and 14.2% of the associations of diabetes with cumulative grip strength and cumulative chair-rising time, respectively. Cumulative grip strength also correlated inversely with blood pressure, glycemia, and inflammation.
Higher cumulative muscle strength was associated with lower risk of diabetes and better cardiometabolic health in middle-aged and older Chinese adults.
以往评估肌肉力量与糖尿病风险之间关联的研究很少考虑随时间的累积暴露情况。本研究调查了中年及老年人群中4年累积肌肉力量与糖尿病风险之间的关联。
我们纳入了无糖尿病的参与者，他们在4年期间对肌肉力量进行了3次重复测量，肌肉力量通过握力（按体重标准化）和从椅子上起身的时间来评估。累积肌肉力量根据梯形法则计算。对累积血压进行了逻辑回归分析和中介分析。
我们分别纳入了3731名和3799名有累积握力和累积从椅子上起身时间数据的参与者。随着累积握力的增加或累积从椅子上起身时间的减少，糖尿病的发病几率逐渐降低，多变量调整后每1个标准差变化的相应比值比分别为0.79和0.89。累积收缩压分别介导了糖尿病与累积握力和累积从椅子上起身时间之间关联的10.8%和14.2%。累积握力也与血压、血糖和炎症呈负相关。
较高的累积肌肉力量与中国中年及老年成年人较低的糖尿病风险和更好的心脏代谢健康状况相关。
