State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, PR China; MIIT Key Laboratory of Multifunctional Lightweight Materials and Structures, Nanjing University of Aeronautics, Nanjing 210016, PR China.
MOE Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, PR China.
Adv Drug Deliv Rev. 2023 Mar;194:114722. doi: 10.1016/j.addr.2023.114722. Epub 2023 Feb 2.
Mechanotherapy is proposed as a new option for cancer treatment. Increasing evidence suggests that characteristic differences are present in the nuclear mechanics and mechanotransduction of cancer cells compared with those of normal cells. Recent advances in understanding nuclear mechanics and mechanotransduction provide not only further insights into the process of malignant transformation but also useful references for developing new therapeutic approaches. Herein, we present an overview of the alterations of nuclear mechanics and mechanotransduction in cancer cells and highlight their implications in cancer mechanotherapy.
力学治疗被提议作为癌症治疗的一种新选择。越来越多的证据表明，与正常细胞相比，癌细胞的核力学和力学转导存在特征差异。对核力学和力学转导的理解的最新进展不仅为恶性转化过程提供了更深入的了解，而且为开发新的治疗方法提供了有用的参考。本文综述了癌细胞核力学和力学转导的改变，并强调了它们在癌症力学治疗中的意义。
