人体多形核白细胞、单核细胞和血小板中的肉碱。

Carnitine in human polymorphonuclear leukocytes, mononuclear cells, and platelets.

作者信息

Katrib K, Adlouni A H, Férard G

机构信息

Department of Applied Biochemistry, Université Louis Pasteur, Strasbourg, France.

出版信息

Am J Clin Nutr. 1987 Nov;46(5):734-5. doi: 10.1093/ajcn/46.5.734.

DOI:10.1093/ajcn/46.5.734

PMID:3673923

Abstract

We tried to study the distribution of carnitine in human blood. Total carnitine (free plus acylcarnitine) was determined in red blood cells, polymorphonuclear leukocytes, mononuclear cells, platelets, and plasma from 15 apparently healthy adults. We did not find carnitine in red blood cells but found it in significant amounts in polymorphonuclear leukocytes and mononuclear cells, 52.2 +/- 16.9 and 41.9 +/- 9.3 mumol/10(9) cells (mean +/- 1 SD), respectively. We also found that platelets contain carnitine in small amounts, 49.0 +/- 8.4 nmol/10(9) cells. In plasma the carnitine concentration was 51.5 +/- 3.3 mumol/L. We conclude that blood carnitine is localized mainly in polymorphonuclear leukocytes and mononuclear cells (83% of whole-blood carnitine).

摘要

我们试图研究肉碱在人体血液中的分布情况。测定了15名貌似健康的成年人红细胞、多形核白细胞、单核细胞、血小板及血浆中的总肉碱（游离肉碱加酰基肉碱）。我们在红细胞中未发现肉碱，但在多形核白细胞和单核细胞中发现了大量肉碱，分别为52.2±16.9和41.9±9.3μmol/10⁹个细胞（平均值±标准差）。我们还发现血小板中含有少量肉碱，为49.0±8.4nmol/10⁹个细胞。血浆中肉碱浓度为51.5±3.3μmol/L。我们得出结论，血液中的肉碱主要存在于多形核白细胞和单核细胞中（占全血肉碱的83%）。