[人外周血单个核细胞和多形核白细胞上的糖皮质激素受体：阳虚患者的变化]

[Glucocorticoid receptors on human peripheral mononuclear and polymorphonuclear leucocytes: changes in patients with yang-deficiency].

作者信息

Zhang J, Liu Z

机构信息

Department of Endocrinology, Changhai Hospital.

出版信息

Zhong Xi Yi Jie He Za Zhi. 1990 Apr;10(4):215-6, 196.

PMID:2401033

Abstract

It was found that, in former works, the glucocorticoid receptors (GCR) on peripheral mixed leucocytes in patients with Yang-deficiency were decreased. In this work, the mixed leucocytes were further separated into mononuclear (MNL) and polymorphonuclear (PML) leucocytes, and GCR were determined in each part of leucocytes. GCR on MNL and PML in 6 Yang deficient patients were 3473 +/- 413 and 4433 +/- 651 sites/cell respectively, statistically significant from the normal control group (4462 +/- 962 and 5622 +/- 782 sites/cell respectively, P less than 0.05). GCR on MNL, PML and mixed leucocytes in 5 patients were determined simultaneously, and all lowered from the control group. The results were 3369 +/- 370, 4986 +/- 419 and 4524 +/- 852 sites/cell respectively, with the lowest GCR on MNL and highest on PML.

摘要

研究发现，在以往的研究中，阳虚患者外周血混合白细胞上的糖皮质激素受体（GCR）减少。在本研究中，将混合白细胞进一步分离为单核细胞（MNL）和多形核白细胞（PML），并分别测定各部分白细胞中的GCR。6例阳虚患者MNL和PML上的GCR分别为3473±413和4433±651位点/细胞，与正常对照组（分别为4462±962和5622±782位点/细胞）相比有统计学意义（P＜0.05）。同时测定了5例患者MNL、PML和混合白细胞上的GCR，均低于对照组。结果分别为3369±370、4986±419和4524±852位点/细胞，其中MNL上的GCR最低，PML上的最高。