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应用决策树分析预测伴或不伴退变性腰椎滑脱和脊柱侧弯的腰椎管狭窄症微创减压手术的临床疗效。

A decision tree analysis to predict clinical outcome of minimally invasive lumbar decompression surgery for lumbar spinal stenosis with and without coexisting spondylolisthesis and scoliosis.

机构信息

Department of Orthopaedic Surgery, Metropolitan University, Graduate School of Medicine, Osaka City, Osaka, Japan.

Department of Orthopaedic Surgery, Metropolitan University, Graduate School of Medicine, Osaka City, Osaka, Japan.

出版信息

Spine J. 2023 Jul;23(7):973-981. doi: 10.1016/j.spinee.2023.01.023. Epub 2023 Feb 4.

Abstract

BACKGROUND CONTEXT

Implementing machine learning techniques, such as decision trees, known as prediction models that use logical construction diagrams, are rarely used to predict clinical outcomes.

PURPOSE

To develop a clinical prediction rule to predict clinical outcomes in patients who undergo minimally invasive lumbar decompression surgery for lumbar spinal stenosis with and without coexisting spondylolisthesis and scoliosis using a decision tree model.

STUDY DESIGN/SETTING: A retrospective analysis of prospectively collected data.

PATIENT SAMPLE

This study included 331 patients who underwent minimally invasive surgery for lumbar spinal stenosis and were followed up for ≥2 years at 1 institution.

OUTCOME MEASURES

Self-report measures: The Japanese Orthopedic Association (JOA) scores and low back pain (LBP)/leg pain/leg numbness visual analog scale (VAS) scores. Physiologic measures: Standing sagittal spinopelvic alignment, computed tomography, and magnetic resonance imaging results.

METHODS

Low achievement in clinical outcomes were defined as the postoperative JOA score at the 2-year follow-up <25 points. Univariate and multiple logistic regression analysis and chi-square automatic interaction detection (CHAID) were used for analysis.

RESULTS

The CHAID model for JOA score <25 points showed spontaneous numbness/pain as the first decision node. For the presence of spontaneous numbness/pain, sagittal vertical axis ≥70 mm was selected as the second decision node. Then lateral wedging, ≥6° and pelvic incidence minus lumbar lordosis (PI-LL) ≥30° followed as the third decision node. For the absence of spontaneous numbness/pain, sex and lateral olisthesis, ≥3mm and American Society of Anesthesiologists physical status classification system score were selected as the second and third decision nodes. The sensitivity, specificity, and the positive predictive value of this CHAID model was 65.1, 69.8, and 64.7% respectively.

CONCLUSIONS

The CHAID model incorporating basic information and functional and radiologic factors is useful for predicting surgical outcomes.

摘要

背景

决策树等机器学习技术很少用于预测临床结果,这些技术被称为预测模型,它们使用逻辑构造图。

目的

使用决策树模型开发一种临床预测规则,以预测接受微创腰椎减压手术治疗腰椎椎管狭窄症合并或不合并脊椎滑脱和脊柱侧凸患者的临床结果。

研究设计/设置:前瞻性收集数据的回顾性分析。

患者样本

这项研究包括在一家机构接受微创脊柱手术治疗腰椎管狭窄症并随访至少 2 年的 331 名患者。

结局测量

自我报告测量:日本骨科协会(JOA)评分和下腰痛(LBP)/腿痛/腿麻木视觉模拟量表(VAS)评分。生理测量:站立矢状位脊柱骨盆排列、计算机断层扫描和磁共振成像结果。

方法

临床结局不佳定义为术后 2 年随访时的 JOA 评分<25 分。采用单变量和多变量逻辑回归分析及卡方自动交互检测(CHAID)进行分析。

结果

JOA 评分<25 分的 CHAID 模型显示自发性麻木/疼痛为第一个决策节点。对于存在自发性麻木/疼痛,选择矢状垂直轴≥70mm 作为第二个决策节点。然后,外侧楔形、≥6°和骨盆入射角减去腰椎前凸(PI-LL)≥30°作为第三个决策节点。对于不存在自发性麻木/疼痛,选择性别和外侧滑椎、≥3mm 和美国麻醉医师协会身体状况分类系统评分作为第二和第三个决策节点。该 CHAID 模型的敏感性、特异性和阳性预测值分别为 65.1%、69.8%和 64.7%。

结论

纳入基本信息以及功能和影像学因素的 CHAID 模型有助于预测手术结果。

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