Castro O, Alarif L, Saxinger C, Frederick W
Department of Medicine, Howard University College of Medicine, Washington, D.C.
Am J Hematol. 1987 Nov;26(3):273-7. doi: 10.1002/ajh.2830260309.
A woman with sickle cell-hemoglobin C disease developed the acquired immunodeficiency syndrome (AIDS), possibly as the result of blood transfusions administered 4 years earlier. Three months after subsequent transfusions, she had excess HLA-A and DR antigens (triplets) on her circulating lymphocytes. Three of her first-degree relatives were HLA-typed, and none had excess antigens. Family studies also indicated that the patient had at least one HLA-A antigen that was probably not inherited. These findings suggest the possibility that transient hemopoietic engraftment can occur in transfused sickle cell patients with AIDS.
一名患有镰状细胞-血红蛋白C病的女性患上了获得性免疫缺陷综合征（艾滋病），可能是4年前输血的结果。在随后的输血3个月后，她循环淋巴细胞上出现了过量的HLA-A和DR抗原（三联体）。对她的3名一级亲属进行了HLA分型，没有一人有过量抗原。家族研究还表明，该患者至少有一个HLA-A抗原可能不是遗传而来的。这些发现提示，在患有艾滋病的镰状细胞病输血患者中可能会发生短暂的造血细胞植入。
