King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
National and Specialist OCD and Related Disorders Clinic for Young People, South London, UK.
Psychol Med. 2022 May;52(7):1268-1276. doi: 10.1017/S0033291720002998. Epub 2020 Sep 17.
Previous research indicates that body dysmorphic disorder (BDD) is associated with risk of suicidality. However, studies have relied on small and/or specialist samples and largely focussed on adults, despite these difficulties commonly emerging in youth. Furthermore, the aetiology of the relationship remains unknown.
Two independent twin samples were identified through the Child and Adolescent Twin Study in Sweden, at ages 18 (N = 6027) and 24 (N = 3454). Participants completed a self-report measure of BDD symptom severity. Young people and parents completed items assessing suicidal ideation/behaviours. Logistic regression models tested the association of suicidality outcomes with: (a) probable BDD, classified using an empirically derived cut-off; and (b) continuous scores of BDD symptoms. Bivariate genetic models examined the aetiology of the association between BDD symptoms and suicidality at both ages.
Suicidal ideation and behaviours were common among those with probable BDD at both ages. BDD symptoms, measured continuously, were linked with all aspects of suicidality, and associations generally remained significant after adjusting for depressive and anxiety symptoms. Genetic factors accounted for most of the covariance between BDD symptoms and suicidality (72.9 and 77.7% at ages 18 and 24, respectively), but with significant non-shared environmental influences (27.1 and 22.3% at ages 18 and 24, respectively).
BDD symptoms are associated with a substantial risk of suicidal ideation and behaviours in late adolescence and early adulthood. This relationship is largely explained by common genetic liability, but non-shared environmental effects are also significant and could provide opportunities for prevention among those at high-risk.
先前的研究表明,身体畸形障碍(BDD)与自杀风险相关。然而,这些研究依赖于小样本和/或专业样本,并且主要集中在成年人身上,尽管这些困难在年轻人中普遍存在。此外,这种关系的病因仍然未知。
通过瑞典儿童和青少年双胞胎研究,在 18 岁(N=6027)和 24 岁(N=3454)时确定了两个独立的双胞胎样本。参与者完成了身体畸形障碍症状严重程度的自我报告测量。年轻人和父母完成了评估自杀意念/行为的项目。逻辑回归模型检验了自杀结果与以下因素的关联:(a)使用经验衍生的截止值分类的可能的 BDD;和(b)BDD 症状的连续评分。双变量遗传模型在两个年龄都检验了 BDD 症状与自杀之间关联的病因。
在两个年龄,有身体畸形障碍的人都有自杀意念和行为。连续测量的 BDD 症状与自杀的各个方面都有关联,并且在调整抑郁和焦虑症状后,关联仍然显著。遗传因素解释了 BDD 症状和自杀之间的大部分协方差(分别为 18 岁和 24 岁的 72.9%和 77.7%),但存在显著的非共享环境影响(分别为 18 岁和 24 岁的 27.1%和 22.3%)。
BDD 症状与青少年晚期和成年早期的自杀意念和行为有很大的风险相关。这种关系主要由共同的遗传易感性解释,但非共享的环境影响也很重要,为高危人群提供了预防的机会。