Department of Burns and Plastic Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233000, PR China.
Department of Burns and Plastic Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233000, PR China.
Asian J Surg. 2023 Oct;46(10):4131-4137. doi: 10.1016/j.asjsur.2023.01.068. Epub 2023 Feb 3.
This systematic review and meta-analysis aim to explore the adjuvant effect of hyperbaric oxygen therapy (HBOT) in patients with venous leg ulcer (VLU) undergoing surgeries and non-surgeries. Literatures were searched from Web of Science, Cochrane Library, Embase, Pubmed, Wan fang, China National Knowledge Infrastructure (CNKI), and VIP from inception to November 15, 2022. The risk ratio (RR) and weighted mean difference (WMD) were used as effect size for categorical variables and continuous variables, respectively, with 95% confidence interval (95%CI). The heterogeneity was assessed using Q-test and quantified as I. Sensitivity analysis was performed for all outcomes. A total of 11 studies were finally included in this study, with a total of 617 patients (313 in the HBOT group and 304 in the control group). Results showed that HBOT in combination with surgeries was associated with shorter ulcer healing time (WMD: -13.76, 95%CI: -20.42 to -7.10), lower VAS score (WMD: -0.95, 95% CI: -1.83 to -0.07), and smaller ulcer area (WMD: -2.64, 95%CI: -3.86 to -1.42). HBOT in combination with non-surgeries was associated with higher ulcer PAR (WMD: 20.82, 95%CI: 5.86 to 35.79), but no statistical significance was found in the improvement of ulcer area (WMD: 0.79, 95% CI: -1.54 to 3.12). Our results indicating that HBOT had a good adjuvant effect in surgeries to treat VLU, and its effect in non-surgeries needed further studies.
本系统评价和荟萃分析旨在探讨高压氧治疗（HBOT）在接受手术和非手术治疗的静脉性腿部溃疡（VLU）患者中的辅助作用。从 Web of Science、Cochrane 图书馆、Embase、PubMed、万方、中国知网（CNKI）和维普数据库检索文献，检索时间从建库至 2022 年 11 月 15 日。采用风险比（RR）和加权均数差（WMD）作为分类变量和连续变量的效应量，置信区间为 95%（95%CI）。采用 Q 检验评估异质性，并以 I ² 表示。对所有结局进行敏感性分析。最终纳入 11 项研究，共 617 名患者（HBOT 组 313 名，对照组 304 名）。结果显示，HBOT 联合手术可缩短溃疡愈合时间（WMD：-13.76，95%CI：-20.42 至-7.10）、降低视觉模拟评分（WMD：-0.95，95%CI：-1.83 至-0.07）、缩小溃疡面积（WMD：-2.64，95%CI：-3.86 至-1.42）。HBOT 联合非手术可提高溃疡愈合百分比（WMD：20.82，95%CI：5.86 至 35.79），但对溃疡面积的改善无统计学意义（WMD：0.79，95%CI：-1.54 至 3.12）。我们的结果表明，HBOT 在手术治疗 VLU 中具有良好的辅助作用，其在非手术治疗中的作用需要进一步研究。
