Klavsen Stephen, Rasmussen Sten
Department of Clinical Medicine, Aalborg University, 9260 Aalborg, Denmark.
Nanomaterials (Basel). 2025 Aug 8;15(16):1213. doi: 10.3390/nano15161213.
Gold nanoparticles (GNPs) are increasingly studied for their potential to enhance wound healing, but their overall efficacy remains uncertain.
We conducted a systematic meta-analysis (search date: 14 May 2025) across five databases. Included were randomized animal studies comparing GNPs to placebo, reporting wound closure percentages and relevant variance measures. Risk of bias was assessed using Cochrane and CAMARADES tools. Cohen's d was used to estimate effect size under a random-effects model.
Thirty-one studies met the inclusion criteria. The pooled effect size was d = 4.52 (95% CI: 3.61 to 5.43; z = 9.73; < 0.001), indicating a significant benefit of GNPs. Although heterogeneity was moderate to high, results consistently favored GNPs.
GNPs significantly accelerate wound healing in animal models, supporting their potential as therapeutic agents.
金纳米颗粒（GNPs）因其促进伤口愈合的潜力而受到越来越多的研究，但其总体疗效仍不确定。
我们对五个数据库进行了系统的荟萃分析（检索日期：2025年5月14日）。纳入的是将金纳米颗粒与安慰剂进行比较的随机动物研究，报告伤口闭合百分比和相关方差测量值。使用Cochrane和CAMARADES工具评估偏倚风险。在随机效应模型下，使用Cohen's d来估计效应大小。
31项研究符合纳入标准。合并效应大小为d = 4.52（95%置信区间：3.61至5.43；z = 9.73；P < 0.001），表明金纳米颗粒具有显著益处。尽管异质性为中度至高，但结果始终支持金纳米颗粒。
金纳米颗粒在动物模型中显著加速伤口愈合，支持其作为治疗剂的潜力。
