Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, PO Box 2457, Riyadh, 11451, Saudi Arabia.
Pharmacol Rep. 2023 Apr;75(2):223-235. doi: 10.1007/s43440-023-00453-9. Epub 2023 Feb 6.
Benzoquinazolines, the essential constituents of numerous well-known heterocyclic systems, have occupied a prominent position and played a significant part in the synthesis of various pharmaceutical compounds. The wide range of pharmacological effects attributed to benzoquinazolines has been the subject of extensive study. These include their roles as anticancer, antimicrobial, anti-monoamine oxidase, anticonvulsant, antiviral, antinociceptive, antioxidant, antineoplastic, antituberculosis, antiplatelet, and antiphlogistic agents. This work provides an attempt at a literature review of the pharmacological activities of benzoquinazoline derivatives, including an up-to-date account of recent research findings, and suggests avenues for future exploration in the pursuit of more potent and specific analogues for a wide range of biological targets using this platform.
苯并喹唑啉是许多著名杂环体系的基本组成部分，在各种药物化合物的合成中占有重要地位。苯并喹唑啉具有广泛的药理作用，这一直是广泛研究的主题。这些作用包括抗癌、抗菌、抗单胺氧化酶、抗惊厥、抗病毒、镇痛、抗氧化、抗肿瘤、抗结核、抗血小板和抗炎作用。这项工作试图对苯并喹唑啉衍生物的药理活性进行文献综述，包括最近研究结果的最新报道，并提出了利用这一平台为广泛的生物靶标寻找更有效和更特异的类似物的未来探索途径。
