桂利嗪治疗慢性哮喘
Cinnarizine in the treatment of chronic asthma.
作者信息
Emanuel M B, Chamberlain J A, Whiting S, Rigden B G, Craven A H
出版信息
Br J Clin Pharmacol. 1979 Feb;7(2):189-95. doi: 10.1111/j.1365-2125.1979.tb00920.x.
Abstract
1 Cinnarizine, an inhibitor of calcium ion transport across smooth muscle cell membrane, has been shown to exert an anti-asthmatic effect in patients with chronic asthma. 2 It is postulated that antagonism to calcium ion transport across the mast cell membrane may cause the compound to have a pharmacological effect similar to sodium cromoglycate. 3 Cinnarizine is orally active and its therapeutic effect is demonstrated in a double-blind, cross-over, placebo controlled study. 4 Patient benefit was shown by a significant improvement in peak flow rate. A non-significant trend towards a reduction in symptomatic bronchodilator usage and a decrease in asthma symptom score was also shown. 5 It is concluded that cinnarizine could well prove to be the first of a new family of anti-asthmatic drugs offering a protective effect when taken systemically.
摘要
- 桂利嗪是一种抑制钙离子跨平滑肌细胞膜转运的药物，已被证明对慢性哮喘患者有抗哮喘作用。2. 据推测，拮抗钙离子跨肥大细胞膜的转运可能使该化合物具有与色甘酸钠相似的药理作用。3. 桂利嗪口服有效，其治疗效果在一项双盲、交叉、安慰剂对照研究中得到证实。4. 峰值流速显著改善表明患者受益。同时还显示出症状性支气管扩张剂使用减少和哮喘症状评分降低的非显著趋势。5. 得出的结论是，桂利嗪很可能被证明是一类新型抗哮喘药物中的第一种，全身服用时具有保护作用。
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Cinnarizine in the treatment of chronic asthma.桂利嗪治疗慢性哮喘
Br J Clin Pharmacol. 1979 Feb;7(2):189-95. doi: 10.1111/j.1365-2125.1979.tb00920.x.
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本文引用的文献
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Cinnarizine in the treatment of peripheral vascular disease: mechanisms related to its clinical action.桂利嗪治疗外周血管疾病：与其临床作用相关的机制
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Further observations on the disruption of rat mesentery mast cells caused by compound 48/80, antigen-antibody reaction, lecithinase A and decylamine.关于化合物48/80、抗原-抗体反应、卵磷脂酶A和癸胺对大鼠肠系膜肥大细胞破坏作用的进一步观察
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EFFECTS OF COMPOUND 48/80, CHYMOTRYPSIN AND ANTI-SERUM ON ISOLATED MAST CELLS UNDER AEROBIC AND ANAEROBIC CONDITIONS.化合物48/80、胰凝乳蛋白酶和抗血清在需氧和厌氧条件下对分离的肥大细胞的作用。
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Human bioassay of antihistaminic agents.抗组胺药的人体生物测定
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Maximum forced expiratory flow rate as a measure of ventilatory capacity: with a description of a new portable instrument for measuring it.作为通气能力指标的最大用力呼气流量率：并介绍一种测量该指标的新型便携式仪器。
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