Durgun Mehmet, Karahan Mehmet Zülkif
Pulmonology, Dağkapı State Hospital, Diyarbakır, TUR.
Cardiology, Mardin Artuklu University Faculty of Medicine, Mardin, TUR.
Cureus. 2023 Jan 2;15(1):e33268. doi: 10.7759/cureus.33268. eCollection 2023 Jan.
The frontal QRS-T angle (fQRS-T) is associated with myocardial ischemia and ventricular arrhythmias. On the other hand, acute pulmonary embolism (APE) is a major risk factor for cardiac adverse events. This research aimed to determine whether the fQRS-T, a marker of ventricular heterogeneity, can be used to predict successful thrombolytic therapy in patients with APE.
This was a retrospective observational study. Patients diagnosed with APE and hospitalized in the intensive care unit between 2020 and 2022 were included in the research. A total of 136 individuals with APEs were enrolled in this research. The patients were divided into two groups: thrombolytic-treated (n=64) and non-treated (moderate to severe risk, n=72). An ECG was conducted for each patient, and echocardiography was performed.
The mean age of the thrombolytic group was 58.2±17.6 years, with 35 females (55.1% of the group) and 29 males (44.9%). The non-thrombolytic group had a mean age of 63.1±16.2, with 41 females (56.5%) and 31 males (43.5%). Respiratory rate, heart rate, and fQRS-T were higher in the thrombolytic group, and oxygen saturation ratio and systolic and diastolic blood pressure were higher in the non-thrombolytic group (p=0.006, p<0.001, p=0.021; p<0.001, p=0.015, p<0.001, respectively). In the thrombolytic therapy group, comparing pre- and post-treatment ECG data revealed a statistically significant change in the fQRS-T value (p=0.019).
The fQRS-T may provide important clues for the successful treatment of APEs.
额面QRS-T角（fQRS-T）与心肌缺血和室性心律失常相关。另一方面，急性肺栓塞（APE）是心脏不良事件的主要危险因素。本研究旨在确定作为心室异质性标志物的fQRS-T是否可用于预测APE患者溶栓治疗的成功与否。
这是一项回顾性观察研究。研究纳入了2020年至2022年间在重症监护病房住院的APE确诊患者。共有136例APE患者参与本研究。患者分为两组：溶栓治疗组（n = 64）和未治疗组（中重度风险，n = 72）。对每位患者进行心电图检查，并进行超声心动图检查。
溶栓组的平均年龄为58.2±17.6岁，其中女性35例（占该组的55.1%），男性29例（44.9%）。非溶栓组的平均年龄为63.1±16.2岁，其中女性41例（56.5%），男性31例（43.5%）。溶栓组的呼吸频率、心率和fQRS-T较高，而非溶栓组的氧饱和度、收缩压和舒张压较高（分别为p = 0.006、p < 0.001、p = 0.021；p < 0.001、p = 0.015、p < 0.001）。在溶栓治疗组中，比较治疗前后的心电图数据发现fQRS-T值有统计学意义的变化（p = 0.019）。
fQRS-T可能为APE的成功治疗提供重要线索。
