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无疱疹样皮炎的乳糜泻患者皮肤中IgA缺失。

Absence of cutaneous IgA in coeliac disease without dermatitis herpetiformis.

作者信息

Karlsson I J, Dahl M G, Marks J M

出版信息

Br J Dermatol. 1978 Dec;99(6):621-5. doi: 10.1111/j.1365-2133.1978.tb07055.x.

DOI:10.1111/j.1365-2133.1978.tb07055.x
PMID:367420
Abstract

Skin biopsies from 17 patients with coeliac disease, but without dermatitis herpetiformis, were examined by direct immunofluorescence. In none of them was IgA detectable. In contrast, IgA was present in dermal papillae and/or in relation to the dermo-epidermal junction in 80 out of 83 patients with dermatitis herpetiformis. These findings confirm that cutaneous deposition of IgA at these sites is a very characteristic feature of dermatitis herpetiformis and is unrelated to coeliac disease itself.

摘要

对17例患有乳糜泻但无疱疹样皮炎的患者进行皮肤活检,并通过直接免疫荧光法进行检查。在这些患者中均未检测到IgA。相比之下,83例疱疹样皮炎患者中有80例在真皮乳头和/或与真皮-表皮交界处存在IgA。这些发现证实,IgA在这些部位的皮肤沉积是疱疹样皮炎的一个非常典型的特征,且与乳糜泻本身无关。

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引用本文的文献

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Increased production of IL-4 by gut T-cell lines from patients with dermatitis herpetiformis compared to patients with isolated gluten-sensitive enteropathy.与孤立性麸质敏感性肠病患者相比,疱疹样皮炎患者肠道T细胞系产生的IL-4增加。
Dig Dis Sci. 2000 Oct;45(10):2036-43. doi: 10.1023/a:1005512513007.
2
Expression of interleukin-4 and interferon-gamma in the small bowel of patients with dermatitis herpetiformis and isolated gluten-sensitive enteropathy.疱疹样皮炎和孤立性麸质敏感性肠病患者小肠中白细胞介素-4和干扰素-γ的表达
Dig Dis Sci. 1999 Oct;44(10):2124-32. doi: 10.1023/a:1026699108147.