Dao Liping, Chen Siyang, Sun Xiangyun, Pang Wenyuan, Zhang Hengzhe, Liao Jun, Yan Jiqiang, Pang Jie
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, China.
College of Computer and Information, Fujian Agriculture and Forestry University, Fuzhou, China.
Front Nutr. 2023 Jan 19;9:1123494. doi: 10.3389/fnut.2022.1123494. eCollection 2022.
To improve the bioavailability of active substances and reduce the toxic and side effects on the human body, natural biological macromolecules are used to load active substances and control their release speed in different environments of the human body. In this study, mesoporous silica (MSN) was combined with konjac glucomannan (KGM) and sodium alginate (AC) to prepare pH-sensitive konjac glucomannan/sodium alginate-mesoporous silica loaded naringin gel spheres (KS/MSN). On this basis, the structure, morphology, and release properties of the composite gel spheres were characterized. The results showed that the cumulative release rates of both simulated gastric fluid (SGF) and Simulated colonic fluid (SCF) were lower than that of simulated small intestinal fluid (SIF), which indicated that the prepared composite gel spheres were pH-sensitive to SIF and obtained the best release rate of about 70% under SIF environment.
The pH-sensitive konjac glucomannan/sodium alginate composite gel spheres (KGM/SA) were prepared by combining inorganic nano-materials mesoporous silica (MSN) with natural macromolecular polysaccharides konjac glucomannan (KGM) and sodium alginate (SA) and characterized.
The results showed that there was a process of ionic crosslinking and entanglement between konjac glucomannan (KGM) and sodium alginate (SA). Naringin (NG) and mesoporous silica (MSN) were successfully compounded and had good compatibility. The gel microstructure diagram showed that the addition of MSN improved the gel properties of KGM, and KGM and SA gel spheres (KGM/SA) had good compatibility with mesoporous silica/naringenin nanoparticles (NG/MSN). The study of the simulated digestive environment of the gastrointestinal release medium showed that Konjac glucomannan/sodium alginate-mesoporous silica loaded naringin gel spheres (KS/NM) composite gel spheres had the best slow-release effect and the highest final-release completion degree in SIF. The release of NG from KS/NM composite gel spheres showed a slow upward trend. The results showed that KS/NM composite gel spheres were pH-sensitive.
The KS/NM composite gel spheres showed obvious pH sensitivity to the release of NG, and the gel spheres had a good sustained release effect on NG.
为提高活性物质的生物利用度并降低其对人体的毒副作用，采用天然生物大分子负载活性物质并控制其在人体不同环境中的释放速度。本研究将介孔二氧化硅（MSN）与魔芋葡甘聚糖（KGM）和海藻酸钠（AC）复合，制备了pH敏感型魔芋葡甘聚糖/海藻酸钠-介孔二氧化硅载柚皮苷凝胶球（KS/MSN）。在此基础上，对复合凝胶球的结构、形态和释放性能进行了表征。结果表明，模拟胃液（SGF）和模拟结肠液（SCF）中的累积释放率均低于模拟小肠液（SIF），这表明所制备的复合凝胶球对SIF具有pH敏感性，且在SIF环境下获得了约70%的最佳释放率。
将无机纳米材料介孔二氧化硅（MSN）与天然高分子多糖魔芋葡甘聚糖（KGM）和海藻酸钠（SA）复合，制备pH敏感型魔芋葡甘聚糖/海藻酸钠复合凝胶球（KGM/SA）并进行表征。
结果表明，魔芋葡甘聚糖（KGM）与海藻酸钠（SA）之间存在离子交联和缠结过程。柚皮苷（NG）与介孔二氧化硅（MSN）成功复合且具有良好的相容性。凝胶微观结构图表明，MSN的加入改善了KGM的凝胶性能，且KGM和SA凝胶球（KGM/SA）与介孔二氧化硅/柚皮苷纳米颗粒（NG/MSN）具有良好的相容性。对胃肠道释放介质模拟消化环境的研究表明，魔芋葡甘聚糖/海藻酸钠-介孔二氧化硅载柚皮苷凝胶球（KS/NM）复合凝胶球在SIF中具有最佳的缓释效果和最高的最终释放完成度。NG从KS/NM复合凝胶球中的释放呈缓慢上升趋势。结果表明，KS/NM复合凝胶球具有pH敏感性。
KS/NM复合凝胶球对NG的释放表现出明显的pH敏感性，且该凝胶球对NG具有良好的缓释效果。
