Wu Hongyi, Bu Nitong, Chen Jie, Chen Yuanyuan, Sun Runzhi, Wu Chunhua, Pang Jie
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Polymers (Basel). 2022 Feb 25;14(5):927. doi: 10.3390/polym14050927.
Konjac glucomannan (KGM) hydrogel has favorable gel-forming abilities, but its insufficient swelling capacity and poor control release characteristics limit its application. Therefore, in this study, oxidized hyaluronic acid (OHA) was used to improve the properties of KGM hydrogel. The influence of OHA on the structure and properties of KGM hydrogels was evaluated. The results show that the swelling capacity and rheological properties of the composite hydrogels increased with OHA concentration, which might be attributed to the hydrogen bond between the KGM and OHA, resulting in a compact three-dimensional gel network structure. Furthermore, epigallocatechin gallate (EGCG) was efficiently loaded into the KGM/OHA composite hydrogels and liberated in a sustained pattern. The cumulative EGCG release rate of the KGM/OHA hydrogels was enhanced by the increasing addition of OHA. The results show that the release rate of composite hydrogel can be controlled by the content of OHA. These results suggest that OHA has the potential to improve the properties and control release characteristics of KGM hydrogels.
魔芋葡甘聚糖（KGM）水凝胶具有良好的凝胶形成能力，但其溶胀能力不足和控释特性较差限制了其应用。因此，在本研究中，使用氧化透明质酸（OHA）来改善KGM水凝胶的性能。评估了OHA对KGM水凝胶结构和性能的影响。结果表明，复合水凝胶的溶胀能力和流变性能随OHA浓度的增加而提高，这可能归因于KGM与OHA之间的氢键，从而形成了致密的三维凝胶网络结构。此外，表没食子儿茶素没食子酸酯（EGCG）被有效地负载到KGM/OHA复合水凝胶中并持续释放。KGM/OHA水凝胶的EGCG累积释放率随着OHA添加量的增加而提高。结果表明，复合水凝胶的释放速率可以通过OHA的含量来控制。这些结果表明，OHA具有改善KGM水凝胶性能和控释特性的潜力。
