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Depatuxizumab mafodotin in EGFR-amplified newly diagnosed glioblastoma: A phase III randomized clinical trial.Depatuxizumab mafodotin 治疗 EGFR 扩增型新诊断胶质母细胞瘤的 III 期随机临床试验。
Neuro Oncol. 2023 Feb 14;25(2):339-350. doi: 10.1093/neuonc/noac173.
2
Development of a Patient Decision Aid to Support Shared Decision Making for Patients with Recurrent High-Grade Glioma.开发一种患者决策辅助工具,以支持复发性高级别胶质瘤患者的共同决策。
Int J Environ Res Public Health. 2022 Jun 16;19(12):7396. doi: 10.3390/ijerph19127396.
3
[The 2021 WHO classification of tumours of the central nervous system].[2021年世界卫生组织中枢神经系统肿瘤分类]
Ann Pathol. 2022 Oct;42(5):367-382. doi: 10.1016/j.annpat.2021.11.005. Epub 2021 Dec 2.
4
Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 study.辅助和同步替莫唑胺治疗1p/19q未共缺失的间变性胶质瘤(CATNON;欧洲癌症研究与治疗组织26053-22054研究):一项随机、开放标签的3期研究的第二次中期分析
Lancet Oncol. 2021 Jun;22(6):813-823. doi: 10.1016/S1470-2045(21)00090-5. Epub 2021 May 14.
5
Comprehensive Genomic Analysis in NRG Oncology/RTOG 9802: A Phase III Trial of Radiation Versus Radiation Plus Procarbazine, Lomustine (CCNU), and Vincristine in High-Risk Low-Grade Glioma.NRG 肿瘤学/RTOG9802 中的全面基因组分析:一项 III 期试验,比较放疗与放疗加洛莫司汀、司莫司汀(CCNU)和长春新碱治疗高危低级别胶质瘤。
J Clin Oncol. 2020 Oct 10;38(29):3407-3417. doi: 10.1200/JCO.19.02983. Epub 2020 Jul 24.
6
CODEL: phase III study of RT, RT + TMZ, or TMZ for newly diagnosed 1p/19q codeleted oligodendroglioma. Analysis from the initial study design.CODEL:新诊断的 1p/19q 共缺失型少突胶质细胞瘤接受放疗、放疗 +TMZ 或 TMZ 治疗的 III 期研究。基于初始研究设计的分析。
Neuro Oncol. 2021 Mar 25;23(3):457-467. doi: 10.1093/neuonc/noaa168.
7
Chemoradiation in elderly patients with glioblastoma from the multi-institutional GBM-molRPA cohort: is short-course radiotherapy enough or is it a matter of selection?多机构 GBM-molRPA 队列中老年胶质母细胞瘤患者的放化疗:短程放疗是否足够,还是一个选择问题?
J Neurooncol. 2020 May;148(1):57-65. doi: 10.1007/s11060-020-03468-x. Epub 2020 May 2.
8
A phase II randomized, multicenter, open-label trial of continuing adjuvant temozolomide beyond 6 cycles in patients with glioblastoma (GEINO 14-01).一项在胶质母细胞瘤患者中进行的 6 周期以上继续辅助替莫唑胺的 II 期随机、多中心、开放标签试验(GEINO 14-01)。
Neuro Oncol. 2020 Dec 18;22(12):1851-1861. doi: 10.1093/neuonc/noaa107.
9
Superiority of temozolomide over radiotherapy for elderly patients with RTK II methylation class, MGMT promoter methylated malignant astrocytoma.替莫唑胺治疗 RTK II 甲基化、MGMT 启动子甲基化恶性星形细胞瘤老年患者的优势。
Neuro Oncol. 2020 Aug 17;22(8):1162-1172. doi: 10.1093/neuonc/noaa033.
10
Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma.最大程度切除增强和非增强肿瘤与新诊断胶质母细胞瘤患者分子亚群生存的关联。
JAMA Oncol. 2020 Apr 1;6(4):495-503. doi: 10.1001/jamaoncol.2019.6143.

成人胶质瘤的治疗:最新进展

Treatment of Adult Gliomas: A Current Update.

作者信息

Lee Joo Ho, Wee Chan Woo

机构信息

Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.

Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea.

出版信息

Brain Neurorehabil. 2022 Nov 29;15(3):e24. doi: 10.12786/bn.2022.15.e24. eCollection 2022 Nov.

DOI:10.12786/bn.2022.15.e24
PMID:36742086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9833488/
Abstract

Gliomas are the most common type of primary brain tumor in adults. Glioma treatment requires a multidisciplinary approach involving surgery, radiotherapy, and chemotherapy. Multiple trials have been conducted to establish the appropriate choice of treatment to achieve long-term survival and better quality of life. This review provides up-to-date evidence regarding treatment strategies for gliomas.

摘要

神经胶质瘤是成人中最常见的原发性脑肿瘤类型。神经胶质瘤的治疗需要多学科方法,包括手术、放疗和化疗。已经进行了多项试验,以确定实现长期生存和提高生活质量的合适治疗选择。本综述提供了关于神经胶质瘤治疗策略的最新证据。