Sudha Ayyagari, Vivekanand Namala
Consultant Pathologist, Medwin Hospitals, Hyderabad, India.
J Cytol. 2010 Oct;27(4):152-4. doi: 10.4103/0970-9371.73306.
Castleman's disease (CD), also called giant lymph nodal hyperplasia, is a lymphoproliferative disorder secondary to lymphoid follicle hyperplasia and marked capillary proliferation with endothelial hyperplasia. It presents as enlarged lymph nodes in the mediastinum, neck, groin, axilla and other sites. On clinical examination as well as gross examination, this disease mimics lymphomas and tuberculosis. Since cytological appearances vary depending on the type and extent of hyperplasia, fine needle aspiration cytology (FNAC) findings may not always be conclusive in all cases. We studied aspirates in two cases of CD, one of which presented with multiple enlarged axillary lymph nodes and the other with enlarged cervical lymph node. Cytology revealed reactive lymphadenitis with hyalinized capillaries and other features. Lymph node excision in both cases confirmed the diagnosis.
卡斯尔曼病（CD），也称为巨大淋巴结增生症，是一种继发于淋巴滤泡增生以及伴有内皮细胞增生的显著毛细血管增生的淋巴增殖性疾病。其表现为纵隔、颈部、腹股沟、腋窝及其他部位的淋巴结肿大。在临床检查和大体检查中，这种疾病类似于淋巴瘤和结核病。由于细胞形态学表现因增生的类型和程度而异，细针穿刺抽吸细胞学检查（FNAC）结果在所有病例中可能并不总是具有决定性意义。我们研究了两例卡斯尔曼病的抽吸物，其中一例表现为多个腋窝淋巴结肿大，另一例表现为颈部淋巴结肿大。细胞学检查显示为伴有透明变性毛细血管及其他特征的反应性淋巴结炎。两例病例的淋巴结切除均证实了诊断。
