Moar V A, Jefferies M A, Mutch L M, Ounsted M K, Redman C W
Br J Obstet Gynaecol. 1978 Dec;85(12):933-7. doi: 10.1111/j.1471-0528.1978.tb15856.x.
In a random controlled trial of methyldopa for the treatment of hypertension in pregnancy presenting before 28 weeks gestation, the newborn in the treated group had relatively smaller head circumferences. This difference persisted at two months of age when correction had been made for birth weight, gestation and sex, but was no longeer detectable at six or twelve months. Within the treated group no relationship was found between neonatal head circumference and the total amount or duration of methyldopa received during pregnancy. Comparison of treated and untreated groups according to the time of entry to the study showed that significant differences in neonatal head circumference were only present in patients who entered between 16 and 20 weeks gestation. It is possible that this could be a sensitive period for the interaction of fetal head growth and the onset of specific treatment in hypertensive pregnancy.
在一项针对妊娠28周前出现的高血压进行甲基多巴治疗的随机对照试验中，治疗组的新生儿头围相对较小。在对出生体重、孕周和性别进行校正后，这种差异在两个月大时仍然存在，但在六个月或十二个月时就不再能检测到。在治疗组中，未发现新生儿头围与孕期接受甲基多巴的总量或持续时间之间存在关联。根据进入研究的时间对治疗组和未治疗组进行比较，结果显示，只有在妊娠16至20周之间进入研究的患者中，新生儿头围存在显著差异。这可能是胎儿头部生长与高血压妊娠中特定治疗开始相互作用的一个敏感期。
