Puri Anisha, Ghosh Subir Kumar, Singh Gurchand, Madan Anita
Department of Anaesthesiology, Maharishi Markandeshwar (Deemed to be) University, Mullana, Ambala, India.
Department of Otolaryngology and Head & Neck Surgery, Maharishi Markandeshwar (Deemed to be) University, Mullana, Ambala, India.
Indian J Otolaryngol Head Neck Surg. 2022 Dec;74(Suppl 3):5739-5743. doi: 10.1007/s12070-021-03062-1. Epub 2022 Apr 28.
Postoperative sore throat (POST) is the eighth most common side effect in the postoperative period. Though it is considered as a minor side effect, it can lead to significant discomfort for the patient. Increased morbidity due to postoperative sore throat could have a big impact on outcomes with an increased economic burden to the nation. To determine the efficacy of ketamine gargle on a postoperative sore throat, we compared ketamine gargle with a normal saline gargle. Furthermore, we studied their efficacy on postoperative cough and hoarseness of voice. We randomly allocated 60 patients of ASA-I and II into two groups equally in patients posted for middle ear surgeries under general anaesthesia. Patients of the group- K were asked to gargle with 40 mg ketamine mixed with 29 ml normal saline preoperatively. Group- C patients were given 30 ml normal saline to gargle. Airway manipulation in all patients was done by senior anesthesiologists in the operating room. Patients were observed and interviewed at 1 h, 6 h, and 24 h after extubation for postoperative sore throat, cough, and hoarseness of voice. In the control group, the incidence of postoperative sore throat at 1 h, 6 h, and 24 h was 50%, 43.3%, and 36.7% respectively. When we compared the incidence in the ketaminegroup (Group-K) with the control group it showed that they were significantly lower (-value ≤ 0.05) at all three observation points. On the other hand, ketamine gargle has no significant protective effect on the severity of postoperative sore throat, cough, and hoarseness of voice. Ketamine gargle in this study, showed significantly effective in attenuating postoperative sore throat in patients undergoing tracheal intubation for elective surgeries.
术后咽痛（POST）是术后第八常见的副作用。尽管它被认为是一种轻微的副作用，但它会给患者带来极大的不适。术后咽痛导致的发病率增加可能会对治疗结果产生重大影响，并给国家带来经济负担的增加。为了确定氯胺酮漱口对术后咽痛的疗效，我们将氯胺酮漱口与生理盐水漱口进行了比较。此外，我们还研究了它们对术后咳嗽和声音嘶哑的疗效。我们将60例ASA-I和II级患者在全身麻醉下进行中耳手术时平均随机分为两组。K组患者术前用40毫克氯胺酮与29毫升生理盐水混合漱口。C组患者用30毫升生理盐水漱口。所有患者的气道操作均由手术室的资深麻醉师进行。在拔管后1小时、6小时和24小时对患者进行观察和询问，了解术后咽痛、咳嗽和声音嘶哑情况。在对照组中，术后1小时、6小时和24小时咽痛的发生率分别为50%、43.3%和36.7%。当我们将氯胺酮组（K组）与对照组的发生率进行比较时，发现在所有三个观察点氯胺酮组的发生率均显著较低（P值≤0.05）。另一方面，氯胺酮漱口对术后咽痛、咳嗽和声音嘶哑的严重程度没有显著的保护作用。本研究中，氯胺酮漱口对择期手术行气管插管患者的术后咽痛减轻显示出显著效果。
