Verma Pankaj Kumar, Rana Amit Kumar, Tripathi Swati, Kumar Shivesh, Upadhyay Deepak
Department of ENT, Integral Institute of Medical Sciences & Research, Lucknow, Uttar Pradesh India.
Department of Otolaryngology and Head Neck Surgery, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh India.
Indian J Otolaryngol Head Neck Surg. 2022 Dec;74(Suppl 3):6313-6320. doi: 10.1007/s12070-021-03049-y. Epub 2022 Jan 8.
Oral submucous fibrosis is a chronic disease affecting oral cavity and sometimes the pharynx. Etiology seems to be local irritants such as capsaicin, tobacco, areca nut and spicy foods. The main concern in this is the management of trismus and burning sensation of the oral mucosa. The aim of this study was to compare various medical treatment protocol of OSMF. 210 patients were divided randomly in 3 groups. In Group A, patients were given biweekly intralesional Hyaluronidase/Dexamethasone for 6 weeks. Group B patients were given tablet Pentoxifylline 400 mg TDS.Group C patients were given Eprisone hydrochloride. All three groups were given Lycopene 10,000 mcg for period of 6 weeks. All patients were given topical Triamcelone for local application. The examinations for mouth opening were repeated at weekly intervals for a period of 6 weeks.The most common complaint was burning sensation in 75.98% cases, difficulty in mouth opening in77.45% and difficulty in swallowing food in 61.76% cases. Group A showed improvement in 41.17% cases presenting with burning sensation followed by decreased mouth opening 39.70%. Group B showed improvement in 45.58% burning sensation, 17.64% with decreased mouth opening. Group C showed improvement in 48.52% patients having pain with spicy food, 32.35% with decreased mouth opening and 17.64% with difficulty in swallowing. We conclude that patients which received intralesional dexamethasone and hyaluronidase along with oral Lycopene showed better clinical and symptomatic improvement, and at present appears to be best non-surgical treatment.
口腔黏膜下纤维化是一种影响口腔，有时也会影响咽部的慢性疾病。病因似乎是辣椒素、烟草、槟榔和辛辣食物等局部刺激物。其中主要关注的是牙关紧闭和口腔黏膜烧灼感的处理。本研究的目的是比较口腔黏膜下纤维化的各种医学治疗方案。210名患者被随机分为3组。A组患者每两周接受一次病灶内注射透明质酸酶/地塞米松，共6周。B组患者服用己酮可可碱片，400毫克，每日三次。C组患者服用盐酸乙哌立松。所有三组患者均服用番茄红素10000微克，为期6周。所有患者均给予局部应用曲安奈德。在6周的时间里，每周重复进行一次张口检查。最常见的主诉是75.98%的病例有烧灼感，77.45%的病例张口困难，61.76%的病例吞咽食物困难。A组中，41.17%有烧灼感的病例症状改善，其次是张口受限改善39.70%。B组中，45.58%的烧灼感症状改善，17.64%的张口受限症状改善。C组中，48.52%吃辛辣食物疼痛的患者症状改善，32.35%的张口受限症状改善，17.64%的吞咽困难症状改善。我们得出结论，接受病灶内注射地塞米松和透明质酸酶以及口服番茄红素的患者在临床和症状方面改善更好，目前似乎是最佳的非手术治疗方法。
