Sadaksharam Jayachandran, Mahalingam Sureshkumar
Department of Oral Medicine and Radiology, Tamil Nadu Government Dental College and Hospital, Chennai, Tamil Nadu, India.
Contemp Clin Dent. 2017 Apr-Jun;8(2):200-204. doi: 10.4103/ccd.ccd_1192_16.
To evaluate the therapeutic efficacy of oral pentoxifylline in the treatment of oral submucous fibrosis (OSMF) patients by assessing the clinical symptoms such as burning sensation, mouth opening, and submucosal layer thickness and echogenicity using ultrasonography, both pre- and post-operatively.
Thirty study subjects were included in the study and divided into two groups in single-blind randomized manner, oral pentoxifylline and dexamethasone group. Burning sensation, mouth opening, ultrasonographic submucosal thickness, and echogenicity were recorded both pre- and post-operatively. Any adverse effects reported by the patients were also noted. The data collected were statistically analyzed, and response to pentoxifylline and intralesional dexamethasone with hyaluronidase was observed using ultrasonography.
A highly significant reduction ( < 0.001) in burning sensation, improvement in mouth opening, and changes in submucosal thickness were noticed in both groups, and significant improvement ( < 0.05) in echogenicity in both the groups was noticed. However, pentoxifylline group showed marginally better improvement than dexamethasone group.
Pentoxifylline can bring about significant improvement in OSMF, which can be used as better alternative where intralesional steroid was contraindicated or not well tolerated.
通过术前和术后评估临床症状，如烧灼感、张口度，以及使用超声检查黏膜下层厚度和回声性，来评估口服己酮可可碱对口腔黏膜下纤维化（OSMF）患者的治疗效果。
30名研究对象纳入本研究，并以单盲随机方式分为两组，即口服己酮可可碱组和地塞米松组。术前和术后均记录烧灼感、张口度、超声检查的黏膜下厚度和回声性。还记录患者报告的任何不良反应。对收集的数据进行统计分析，并使用超声观察己酮可可碱和病灶内注射地塞米松联合透明质酸酶的疗效。
两组患者的烧灼感均显著降低（<0.001），张口度改善，黏膜下厚度改变，两组的回声性均有显著改善（<0.05）。然而，己酮可可碱组的改善略优于地塞米松组。
己酮可可碱可使口腔黏膜下纤维化有显著改善，在病灶内注射类固醇禁忌或耐受性不佳的情况下，可作为更好的替代药物。
