Youssefy Abolqasem, Ghabasiah AmirHossein, Heidari Farrokh, Alvandi Sepideh, Bastaninezhad Shahin, Hosseini Jawad, Tajdini Ardavan
Anesthesiology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Otorhinolaryngology Research Center, Amiralam Hospital, Tehran University of Medical Sciences, North Sa'adi Ave, Enghelab Blv, Tehran, Iran.
Indian J Otolaryngol Head Neck Surg. 2022 Dec;74(Suppl 3):4761-4765. doi: 10.1007/s12070-021-03046-1. Epub 2022 Jan 17.
This clinical trial discusses the efficacy of premedication with desmopressin in the management of bleeding and clears the surgical field during rhinoplasty surgery. This study is a randomized, double-blinded placebo-control clinical trial. Seventy patients were enrolled in this study and divided into two equal intervention-control groups. Thirty minutes before surgery, the intervention group received 500 ml of normal saline containing 0.1 μg/kg desmopressin and, the control group received 500 ml of normal saline. According to the surgeon's opinion, the local distribution of bleeding was dramatically different in both groups. While DDAVP receivers had grade 1 or 2 bleeding (according to the FROMME-BOEZAART grading score), the control group had grade 3 or 4 bleeding, and this difference was statistically meaningful. It seems that intravenous DDAVP can reduce bleeding and clear the surgical field during rhinoplasty surgery, but further studies are needed to determine the exact role and dose of the DDAVP.
这项临床试验探讨了去氨加压素术前用药在鼻整形手术中控制出血和清理手术视野方面的疗效。本研究是一项随机、双盲、安慰剂对照的临床试验。70名患者参与了本研究，并被分为两个相等的干预-对照组。手术前30分钟，干预组接受500毫升含0.1微克/千克去氨加压素的生理盐水，对照组接受500毫升生理盐水。根据外科医生的意见，两组的局部出血分布有显著差异。去氨加压素受体组有1级或2级出血（根据FROMME-BOEZAART分级评分），而对照组有3级或4级出血，且这种差异具有统计学意义。静脉注射去氨加压素似乎可以减少鼻整形手术中的出血并清理手术视野，但需要进一步研究来确定去氨加压素的确切作用和剂量。
