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合并人类免疫缺陷病毒感染的二期梅毒中的前带现象：两例报告

Prozone phenomenon in secondary syphilis with HIV co-infection: Two cases.

作者信息

Awake Praneet, Angadi Kalpana, Sen Sourav, Bhadange Prasad

机构信息

Department of Dermatology, Venereology and Leprosy, Symbiosis Medical College for Women, Symbiosis International University, Pune, Maharashtra, India.

Department of Microbiology, Symbiosis Medical College for Women, Symbiosis International University, Pune, Maharashtra, India.

出版信息

Indian J Sex Transm Dis AIDS. 2022 Jul-Dec;43(2):183-185. doi: 10.4103/ijstd.ijstd_43_22. Epub 2022 Nov 17.

DOI:10.4103/ijstd.ijstd_43_22
PMID:36743087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9891016/
Abstract

Prozone phenomenon is defined as a false-negative response resulting from higher antibody titer which interferes with formation of antigen-antibody lattice, necessary to visualize a positive flocculation test. The prozone effect can be observed in syphilis testing with cases of very high antibody titers, such as secondary syphilis, or with human immunodeficiency virus (HIV) co-infection. We report two cases of prozone phenomenon in secondary syphilis with HIV co-infection who initially tested nonreactive for rapid plasma reagin test but tested positive with further higher dilution.

摘要

前带现象被定义为由于抗体滴度较高导致的假阴性反应，这种高抗体滴度会干扰抗原 - 抗体晶格的形成，而抗原 - 抗体晶格的形成是使絮凝试验呈阳性所必需的。在前带效应可在梅毒检测中观察到，如在二期梅毒等抗体滴度非常高的病例中，或在合并人类免疫缺陷病毒（HIV）感染的情况下。我们报告了两例合并HIV感染的二期梅毒患者出现前带现象的病例，这些患者最初快速血浆反应素试验结果为阴性，但进一步进行更高稀释度检测后呈阳性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e4d/9891016/9bdf5297e101/IJSTD-43-183-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e4d/9891016/9bdf5297e101/IJSTD-43-183-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e4d/9891016/9bdf5297e101/IJSTD-43-183-g001.jpg

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本文引用的文献

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Clin Infect Dis. 2014 Aug 1;59(3):384-9. doi: 10.1093/cid/ciu325. Epub 2014 May 6.
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Case series of syphilis and HIV co-infections.梅毒和 HIV 合并感染的病例系列。
Pak J Med Sci. 2013 May;29(3):856-8. doi: 10.12669/pjms.293.3346.
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Prozone phenomenon in secondary syphilis.二期梅毒中的前带现象。
Indian J Sex Transm Dis AIDS. 2011 Jan;32(1):47-9. doi: 10.4103/0253-7184.81256.
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Syphilis and HIV infection: an update.梅毒与艾滋病毒感染：最新情况
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Prozone phenomenon in secondary syphilis. Has its time arrived?二期梅毒中的前带现象。它的时代已经到来了吗？
Arch Intern Med. 1993 Nov 8;153(21):2496-8.
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Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome.获得性免疫缺陷综合征患者B细胞激活及免疫调节异常
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Alteration in the natural history of neurosyphilis by concurrent infection with the human immunodeficiency virus.人类免疫缺陷病毒合并感染对神经梅毒自然病程的影响。
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