Ranade Manjiri, Mudgalkar Nikhil
Department of Rasa Shastra and Bhaishajya Kalpana, Sri Sai Ayurvedic Medical College, Aligarh, Uttar Pradesh, India.
Department of Anesthesia and Critial Care, Prathima Institute of Medical Sciences, Nagnur Road, Karimnagar, Telangana, India.
Ayu. 2021 Jan-Mar;42(1):35-38. doi: 10.4103/ayu.ayu_457_20. Epub 2022 Dec 7.
Hypogalactia is the common condition, especially in preterm deliveries. Some herbs in Indian medicines such as () have galactogogeus effects. The galactogogeus effect of has not been quantified in randomized control trials in humans till date. We intend to study the galactogogeus effects of in hypogalactic mothers through an open-label noncross-over trial.
The target population were women who had delivered infants <32 weeks gestation with no lower limit to gestational age and their babies admitted in neonatal intensive care unit for prematurity. Participants who were taking specific drugs as a result of their primary illnesses, such as chemotherapy, sedatives, or antiseziure medications, were excluded. The randomization was achieved with computer-generated random number table. The experimental group ( = 23) received 2.5 g of ) seeds each day, soaked in luke warm water for half an hour in the morning, along with instructions about how to take the seeds. The control group did not receive any medication ( = 23). According to the institutional procedure, participants were trained to express breast milk six times using a breast pump. The amount of milk extracted was measured every day for 28 days. The difference in milk production between the two groups at 28 days was the primary endpoint. The secondary endpoint was to asses if any of the trial medicines had any adverse drug effects.
A total of 46 participants completed the study till 28 days. In both groups, demographic factors were comparable. The study group surpassed the control group in terms of breast milk volume slowly and reached statistical significance ( = 0.00002) after 28 days of therapy. No adverse drug effects were reported by the participants.
There was statistically significant improvement in breast milk production at 28 days in hypogalactic mothers in the experimental group. can be used as cheap alternatives to costly medicines to improve lactation with minimal costs and no adverse drug reactions.
乳汁分泌不足是一种常见情况，尤其是在早产分娩中。印度医学中的一些草药，如（此处原文括号内内容缺失）具有催乳作用。迄今为止，在人类随机对照试验中，（此处原文缺失草药名称）的催乳作用尚未被量化。我们打算通过一项开放标签的非交叉试验研究（此处原文缺失草药名称）对乳汁分泌不足的母亲的催乳作用。
目标人群为孕周小于32周分娩婴儿且孕周无下限的妇女及其因早产入住新生儿重症监护病房的婴儿。因原发性疾病正在服用特定药物（如化疗药、镇静剂或抗癫痫药物）的参与者被排除。通过计算机生成的随机数字表进行随机分组。实验组（n = 23）每天服用2.5克（此处原文缺失草药名称）种子，早上用温水浸泡半小时，并给予服用种子的相关指导。对照组不接受任何药物治疗（n = 23）。根据机构程序，指导参与者使用吸奶器每天吸乳6次。连续28天每天测量吸出的乳汁量。两组在28天时乳汁分泌量的差异为主要终点。次要终点是评估任何一种试验药物是否有药物不良反应。
共有46名参与者完成了为期28天的研究。两组的人口统计学因素具有可比性。研究组的母乳量增长缓慢超过对照组，治疗28天后达到统计学显著性（P = 0.00002）。参与者未报告药物不良反应。
实验组乳汁分泌不足的母亲在28天时乳汁分泌有统计学显著改善。（此处原文缺失草药名称）可作为昂贵药物的廉价替代品，以低成本改善泌乳且无药物不良反应。
