Xia Yang, Li Qin, Zhong Changgao, Wang Kopen, Li Shiyue
Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Cancer Center, Zhejiang University, Hangzhou, China.
Ther Adv Chronic Dis. 2023 Jan 27;14:20406223221146723. doi: 10.1177/20406223221146723. eCollection 2023.
As the leading cause of cancer-related deaths worldwide, early detection and diagnosis are crucial to reduce the mortality of lung cancer. To date, the diagnosis of the peripheral pulmonary lesions (PPLs) remains a major unmet clinical need. The urgency of diagnosing PPLs has driven a series of development of the advanced bronchoscopy-guided techniques in the past decades, such as radial probe-endobronchial ultrasonography (RP-EBUS), virtual bronchoscopy navigation (VBN), electromagnetic navigation bronchoscopy (ENB), bronchoscopic transparenchymal nodule access (BTPNA), and robotic-assisted bronchoscopy. However, these techniques also have their own limitations. In this review, we would like to introduce the development of diagnostic techniques for PPLs, with a special focus on biopsy approaches and advanced guided bronchoscopy techniques by discussing their advantages, limitations, and future prospects.
作为全球癌症相关死亡的主要原因，早期检测和诊断对于降低肺癌死亡率至关重要。迄今为止，外周肺病变（PPLs）的诊断仍然是一项尚未满足的重大临床需求。在过去几十年中，诊断PPLs的紧迫性推动了一系列先进的支气管镜引导技术的发展，如径向探头支气管内超声检查（RP-EBUS）、虚拟支气管镜导航（VBN）、电磁导航支气管镜（ENB）、支气管镜透明实质结节穿刺术（BTPNA）和机器人辅助支气管镜检查。然而，这些技术也有其自身的局限性。在本综述中，我们将介绍PPLs诊断技术的发展，特别关注活检方法和先进的支气管镜引导技术，讨论它们的优点、局限性和未来前景。
