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关于不同年龄和风险群体中新冠病毒感染所致肝损伤的评论

Commentary on COVID-19-induced liver injury in various age and risk groups.

作者信息

Özdemir Öner, Arsoy Hacer Efnan Melek

机构信息

Department of Pediatrics, Sakarya University, Medical Faculty, Sakarya 54100, Türkiye.

出版信息

World J Virol. 2023 Jan 25;12(1):44-52. doi: 10.5501/wjv.v12.i1.44.

Abstract

Towards the end of 2019, a new type of coronavirus, severe acute respiratory syndrome, emerged in the city of Wuhan in China's Hubei Province. The first occurrence was described as a case of pneumonia. Coronavirus disease 2019 (COVID-19) can progress primarily with symptoms varying from a mild upper respiratory tract infection to severe pneumonia, acute respiratory distress syndrome, and death. Determining the mechanisms of action of this virus, which can affect all systems including gastrointestinal, is vital for predicting the progression of the disease and managing its treatment. It is important to demonstrate the mechanisms of action of COVID-19 in patients without a previously known chronic or systemic disease. Although there is still no specific treatment for the virus, various algorithms have been created. As a result of the applied algorithms, the response to the treatment was satisfactory in some patients, while unexpected side effects occurred in some patients. It helps to clarify whether the unwanted effects that occur are due to the effect of the disease or the side effects of the drugs used in the treatment. There is currently increasing interest in COVID-19 interaction with liver tissue. Therefore, we would like to discuss the details of liver injury/dysfunction in the current literature.

摘要

2019年末,一种新型冠状病毒——严重急性呼吸综合征在中国湖北省武汉市出现。首次发现时被描述为一例肺炎病例。2019冠状病毒病(COVID-19)主要表现为症状多样,从轻度上呼吸道感染到严重肺炎、急性呼吸窘迫综合征,甚至死亡。确定这种能影响包括胃肠道在内的所有系统的病毒的作用机制,对于预测疾病进展和管理治疗至关重要。证明COVID-19在无既往已知慢性或全身性疾病患者中的作用机制很重要。尽管目前仍没有针对该病毒的特效治疗方法,但已创建了各种算法。应用这些算法后,部分患者对治疗的反应令人满意,而部分患者出现了意想不到的副作用。这有助于明确所出现的不良影响是由疾病本身导致,还是治疗所用药物的副作用所致。目前,人们对COVID-19与肝组织的相互作用越来越感兴趣。因此,我们想讨论当前文献中肝损伤/功能障碍的细节。

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