新型冠状病毒大流行:临床概述。

Novel coronavirus pandemic: A clinical overview.

作者信息

Kaswa Ramprakash, Govender Indiran

机构信息

Department of Family Medicine and Rural Health, Walter Sisulu University, Mthatha.

出版信息

S Afr Fam Pract (2004). 2020 Jun 26;62(1):e1-e5. doi: 10.4102/safp.v62i1.5123.

Abstract

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent public health crisis threatening the current world health establishment. The SARS-Co-2 was first identified in Wuhan, Hubei Province, China, in December 2019. There have been about 6.5 million reported cases of coronavirus disease 2019 (COVID-19) and about 350 000 reported deaths throughout the world within the last 6 months from the onset of the epidemic. The virus is primarily transmitted by inhalation or contact with infected droplets. The COVID-19 patient usually presents with fever, cough, sore throat and breathlessness. Currently, available data indicate that the majority of people with the disease have mild symptoms, while about 20% present with moderate-to-severe disease. About 5% of these may progress to pneumonia, acute respiratory distress syndrome and multi-organ dysfunction. To date, there is no recommended medical treatment, and supportive measures are a crucial part of management. The case fatality rate of SARS-CoV-2 is lower than that of its two coronavirus predecessors, that is, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). The full impact of this new pandemic on health, social and economic well-being of humankind is yet to be ascertained.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的爆发是一场危及当前世界卫生体系的突发公共卫生危机。2019年12月,SARS-CoV-2在中国湖北省武汉市首次被发现。自疫情爆发以来的过去6个月里,全球报告了约650万例2019冠状病毒病(COVID-19)病例,约35万人死亡。该病毒主要通过吸入或接触受感染的飞沫传播。COVID-19患者通常表现出发热、咳嗽、喉咙痛和呼吸急促。目前,现有数据表明,大多数患者症状较轻,约20%的患者表现为中重度疾病。其中约5%可能进展为肺炎、急性呼吸窘迫综合征和多器官功能障碍。迄今为止,尚无推荐的药物治疗方法,支持性措施是治疗的关键部分。SARS-CoV-2的病死率低于其两种冠状病毒前身,即严重急性呼吸综合征冠状病毒(SARS-CoV)和中东呼吸综合征冠状病毒(MERS-CoV)。这场新的大流行对人类健康、社会和经济福祉的全面影响尚待确定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c10/8377866/338efd639d61/SAFP-62-5123-g001.jpg

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