Cheng Qian, Sun Jianfei, Ge Yuqing, Xue Le, Mao Hongju, Zhou Lin, Zhao Jianlong
State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai200050, China.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing100049, China.
ACS Sens. 2023 Feb 24;8(2):793-802. doi: 10.1021/acssensors.2c02377. Epub 2023 Feb 6.
Magnetic-sensitive proteins are regarded as key factors in animals' precise perception of the geomagnetic field. Accurate feedback on the response of these tiny proteins to magnetic fields remains a challenge. Here, we first propose a real-time accurate magnetic sensor based on the MagR/Cry4 complex-configured graphene transistor with an integrated on-chip gate. A nanometer-thick denatured bovine serum albumin film was used as the bio-interface of graphene electrolyte-gated transistors (EGTs) to immobilize the MagR/Cry4 complex. With the optimization and characterization of this bionic graphene EGT, it could detect magnetic fields in real time with a sensitivity of 1 mT, which is far lower than in earlier research. It was concluded that our MagR/Cry4 complex-configured graphene EGTs with a side-gate held great promise in terms of geomagnetic field detection. Furthermore, the constructed approach in this paper could also be utilized as a general solution for recording the response of magnetically sensitive biomolecules to magnetic fields in real time.
磁敏蛋白被视为动物精确感知地磁场的关键因素。准确反馈这些微小蛋白对磁场的响应仍然是一项挑战。在此，我们首次提出一种基于具有集成片上栅极的MagR/Cry4复合结构石墨烯晶体管的实时精确磁传感器。使用纳米厚的变性牛血清白蛋白膜作为石墨烯电解质门控晶体管（EGT）的生物界面，以固定MagR/Cry4复合物。通过对这种仿生石墨烯EGT的优化和表征，它能够以1 mT的灵敏度实时检测磁场，这远低于早期研究中的灵敏度。得出的结论是，我们具有侧栅极的MagR/Cry4复合结构石墨烯EGT在地磁场检测方面具有很大的前景。此外，本文构建的方法还可作为实时记录磁敏生物分子对磁场响应的通用解决方案。
